“near-significant”

The pooled SMD was 0.48 (95% CI: −0.04 to 0.99; P = 0.0537; I 2 = 0%), showing a near-significant improvement with DFP (Fig. 4 D).

In particular, a near-significant heterogeneity in our results may suggest possible sources of heterogeneity.

It nevertheless seems worth mentioning the near-significant difference found for school environment, which had a lower score after classroom teaching.

Let us now analyze one-by-one some of the most significant and near-significant adverse effects of the REGENERATE trial and try to mechanistically rationalize their occurrence.

No significant trauma moderation effects were found for IL-6 and connectivity after multiple comparisons adjustment (adjusted p s > .05), although near-significant associations before multiple comparisons adjustment are described in Table S4 .

In the case of TW, electrolyte concentration exhibits the largest linear contribution among all factors, with an F-value of 4.80 and a p-value of 0.053, indicating a near-significant influence on thickness wear.

Remarkable spatial heterogeneity of associations between brain dynamics is observed: for the associations between LBD and within-ICN FCD, DMN has the strongest negative correlation among ICNs (although it is near-significant for the comparison with the correlation of cerebellum network); for the associations between LBD and between-ICN FCD, frontal-parietal network has the smallest correlation and CON has significantly larger correlation than frontal-parietal network, occipital network and sensorimotor network have.

A recent cross-sectional nutrigenetic study in a Saudi adult cohort reported a near-significant interaction between TCF7L2 rs7903146 and total energy and saturated fat intake on insulin concentrations, with TT carriers showing greater reductions in insulin levels under lower-energy dietary conditions ( Al-odinan et al., 2025 ).

Also, phenolic acids showed a near-significant positive relationship with weight during the first trimester and on average.

Cement shade had a near-significant influence on final color perception, particularly with e.max ZirCAD on CrCo substrates.

This biphasic modeling indicated a significant increasing trend (before 7 weeks) of both ERR and EAR ( Table 3 , see γ 1 values) and a near-significant decreasing trend (after 7 weeks) of ERR and EAR, respectively ( Table 3 , see γ 2 values).

Additionally, some phenotypes, such as IMTP absolute peak force (β = 537.93, p = 0.066) and rectus femoris thickness (β = 0.25, p = 0.084), demonstrated near-significant trends that may carry biological relevance.

While our sample size limits definitive conclusions, we observed a tendency toward prolonged PTT and a near-significant extension of PT in the Inf hypo group.

We observed a near-significant relationship between pre-dose fasting time and both C max and AUC 0–24h values, despite the latter being known to be less sensitive to the effect of food.

On evaluating the different degrees of pneumatisation in the cases demonstrating an association between canal and tegmen dehiscence by sex, we observed that in women, the majority of cases presented grade II pneumatisation, while men presented a near-significant relationship with grade III pneumatisation.

At the same time, sex itself emerged as a significant or near-significant covariate in most models, with negative coefficients indicating lower AHI values in female participants.

, and significant increases in branched-chain fatty acids isobutyrate, isovalerate and near-significant higher levels of the SCFA butyrate; however, no significant association with alpha diversity was found [ 224 ]. 7.

All four exposures taken singly had near-significant prevalence ratios ( table 2 ), though reduction of all four exposures by 25% was associated with a 13% (95% CI 2% to 22%) lower prevalence of diabetes, compared with a 40% reduction in diabetes prevalence in association with an identical (25%) reduction in BMI.

The consistent directionality and near-significant p -values observed in multivariate analyses suggest that 25(OH)D may remain relevant but could not be fully captured given the sample size and analytic framework.

I would hesitate advertising the MR performance effect in the visual abstract as it is of dubious reliability because of the near-significant baseline effect and very low N.

87.8%), with near-significant differences across subtypes (Table 2 ).

The comparison with the propensity score-match cohort washed away several significant or near-significant findings from the comparison with all non-BHI-grantee comparison.

Notably, within the erythrocyte profile, the OG group exhibited a significant increase in red blood cell (RBC) count and hemoglobin levels, along with a near-significant rise in hematocrit, suggesting mild erythropoietic stimulation.

In the last phase of this study, all the statistically significant or near-significant variables demonstrated in this revised TO-PIRO Score (rTO-PIRO) were analyzed and used to build up the SORRISO Score.

The near-significant trend observed here may reflect the established epidemiological pattern, but larger sample sizes would be required to confirm whether group differences are robust.