“nominally significant”

3 ), with similar but only nominally significant ( p < 0.05) findings observed for the separate autologous ( p = 0.018) and allogeneic ( p = 0.015) subgroups.

Separately, an excess significance test was conducted using the χ 2 test to investigate whether the observed number of studies with nominally significant results (O;”positive” studies, P < 0.05) differed from the expected number of significant results (E).

Many of our networks had nominally significant (p < 0.05) overlaps with the cell-type-specific DEGs in neuronal cell types, which include both upper and deep layer excitatory neurons and inhibitory interneurons ( Figure 3 C and Table S12 ).

Given the possibility that the observed lack of correlation for LDL-C could be due to reduced power from a limited number of variants attaining a suggestive p -value (<5 × 10 −07 ), we repeated the analysis with a subset of 122 nominally significant ( p -value < 0.05) LDL-C associated variants in this locus.

Three MR models (IVW, weighted median, and GSMR) demonstrated nominally significant ( p < 0.05) causal effect of IPF on CAD, with the estimated liability-scale odds ratios (ORs) ranging from 1.08 to 1.38 (Table 2 ).

Moreover, sensitivity gene-burden tests considering only those additional carriers identified by WGS (that is, not identified by WES data), 16 of the 23 gene masks with at least five carriers showed a nominally significant association ( P < 0.05) with the target phenotype, indicating that the additional coding variants identified by WGS are likely to be functionally relevant.

Therefore, only nominally significant (unadjusted p -value <0.05) rG are reported in the figure.

Regarding descriptive statistics on rumination, gender, age, lifetime psychiatric problems, and present somatic disorders, Supplementary Table 1 shows that except for frequency of pain problems there are differences between the Budapest and Manchester subsamples in all variables at either a nominally significant ( p ≤ 0.05) or trend (0.05 < p ≤ 0.10) level.

We took into account only those genes that reached significance (nominally significant p -value < 0.05).

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

Almost all these genes showed a tendency towards downregulation at T3, and 9 of them exhibited a nominally significant decrease of expression after surgery (P<0.05).

Sentinel variants (defined as the variant in an association signal where no other variants within 1 Mb showed a stronger association) of the novel signals reaching genome-wide significance in the meta-analysis ( P < 5 × 10 −8 ), and nominally significant ( P < 0.05) with consistent direction of effect in each study, were further tested in the replication samples.

No interactions were nominally significant ( p value > 0.05; Additional file 2 : Appendix B).

Most of these loci are not even nominally significant ( P < 0.05) in comparison studies.

Although the DM subgroup result was nominally significant ( p < 0.05), it did not remain statistically significant after Bonferroni correction for four subgroup comparisons (adjusted significance threshold p < 0.0125).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

Predicted impact of ASC-EV-derived miRNAs on cellular processes The enrichment pathway analyses with the miRNA expression correlations and predicted targets was made by matching the top-60 enriched miRNAs in ASC-EVs with predicted mRNA targets in miRWalk (Suppl data 2 , complete list of nominally significant genes, p-value < 0.05 for each miRNA) and subsequent GO enrichment analyses showed a preponderance for mRNAs affected by miR-1290, miR23/27/24 cluster and the miR-15/107 family with no less than 15,870 mRNAs to be targeted by those enriched ASC-EVs-derived miRNAs.

Logistic regression analysis under the additive genetic model (Table S2 ) revealed 3 nominally significant SNPs with p < 0.05 ( PLG /rs4252120, KIAA1462 /rs2505083, and SLC22A3-LPAL2-LPA /rs2048327) and 2 SNPs showing a trend for association with p < 0.10 ( SORT1 /rs602633 and SMG6 /rs2281727) ( Table 2 ).

Association analysis was performed on these 7,369 transcripts which resulted in the identification of 461 FDR-significant GA-related transcripts (1,611 nominally significant transcripts; nominal p -value < 0.05).

It is essential to note that all reported P values are merely nominally significant ( P < .05), but none remained statistically significant after Bonferroni correction.

In a replication study of the 18 novel loci, findings from the HF GWAS in the GBMI multi-ancestry excluding UK Biobank indicate 33.3% (6 of 18) of variants are significant ( p value <0.05/18), 61.1% (11 of 18) are nominally significant ( p value <0.05), and 100% have a beta estimate that is directionally concordant with our meta-analysis (Supplementary Data 20 ).

1815 genes were found to be differentially expressed at a nominally significant level (p<0.05); 809 decreased in expression in the KD samples, while 1106 increased.

Considering the modest number of significantly modified genes upon Dek overexpression by adjusted P -value, we performed pathway analysis on genes with nominally significant P -values ( P -value < 0.05).

These 25 marks were tested for association with prostate cancer, and nominally significant associations (p < 0.05) with aggressive prostate cancer were found for all 9 marks near VTRNA2-1 (Table 1 ), with most remaining nominally significant after dichotomising (Supplementary Table 2), (as previously reported, based on the same datasets [ 5 ]).

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.