“nominally significant”

However, there are over 200 nominally significant between-breed genetic correlations but less than 50 phenotypic correlations compared with an expected error of 20 at p < 0.05.

A significant association was determined if (1) the p -value for the cross-trait meta-analysis reached genome-wide significance ( p < 5 × 10 −8 ) and (2) the univariate GWAS effects were at least nominally significant ( p < 0.05).

3.4 Multivariate regression to maximize the association with subjective cognitive decline scores All variables which were nominally significant (p < 0.05) in the competitive model analysis, in addition to covariates, were then selected as input variables in a backwards stepwise multiple regression analysis to maximize the R adj 2 value ( Fig. 3 A ).

Of the 75 SNPs found in whites, 34 (46%) were nominally significant at P < 0.05 in Japanese, with 18 at P < 0.0005.

Causal estimates produced by the different methods had consistent direction of effect compared to the IVW estimate and all save MR-Egger were nominally significant (i.e. p < 0.05).

Many of our networks had nominally significant (p < 0.05) overlaps with the cell-type-specific DEGs in neuronal cell types, which include both upper and deep layer excitatory neurons and inhibitory interneurons ( Figure 3 C and Table S12 ).

The majority of associations were nominally significant (raw P <0.05), and many also remained FDR significant.

A confirmatory look at candidates previously proposed to be involved in ECT mechanisms found CpG sites associated with response only at the nominally significant level ( p < 0.05).

The levels of all proteins (regardless of storage-time) with nominally significant ( p < 0.05) contributions were subsequently adjusted for age and/or plasma/serum by removing the contribution using the beta (β)-coefficient(s) from the linear models.

Of the 279 gene–trait associations for which we attempted replication, 193 (69%; 28 with a binary trait, 165 with a quantitative trait) were nominally significant ( P ≤ 0.05) and directionally consistent (Supplementary Table 6 ), versus around 7 expected by chance (279 × 0.05 × 0.5).

In unadjusted analyses, 26 SNPs from nine loci were associated with TC, 22 SNPs from 10 loci with LDL, 58 SNPs from 13 loci with HDL, and 40 SNPs from 14 loci with logTG at the nominally significant level ( P < 0.05).

Therefore, only nominally significant (unadjusted p -value <0.05) rG are reported in the figure.

3 ), with similar but only nominally significant ( p < 0.05) findings observed for the separate autologous ( p = 0.018) and allogeneic ( p = 0.015) subgroups.

Of those, 38,776 (95%) showed the same direction of effect, 33,128 (81%) also had a nominally significant p value ( p < 0.05), and 25,544 (63%) had an FDR-adjusted p < 0.05 in the BLUEPRINT data (Fig. 1b , Supplementary Data 1 ).

So it should be kept in mind that each individual p value has a one-in-twenty chance of being nominally significant (p < 0.05) purely from random fluctuations.

Separately, an excess significance test was conducted using the χ 2 test to investigate whether the observed number of studies with nominally significant results (O;”positive” studies, P < 0.05) differed from the expected number of significant results (E).

Moreover, sensitivity gene-burden tests considering only those additional carriers identified by WGS (that is, not identified by WES data), 16 of the 23 gene masks with at least five carriers showed a nominally significant association ( P < 0.05) with the target phenotype, indicating that the additional coding variants identified by WGS are likely to be functionally relevant.

To further explore these regions, we applied more relaxed criteria and detected two nominally significant eQTLs ( P < 0.05) in the NJMU lung eQTL database: MTAP at 9p21.3 and TCF7L2 at 10q25.2 (Additional file 2: Fig.

Associations of Gut Fungi with Postprandial Glycemic Responses to Dietary Intervention We found 12 nominally significant associations between the above-identified gut fungi and glycemic metrics ( p < 0.05, Supplementary Tables S8 and S9 ).

Nominally significant pairwise correlations (one-sided P < 0.05) between peripheral blood and mean brain expression levels of individual miRNAs were observed for 39 and 44 miRNAs in each group.

It is essential to note that all reported P values are merely nominally significant ( P < .05), but none remained statistically significant after Bonferroni correction.

Predicted impact of ASC-EV-derived miRNAs on cellular processes The enrichment pathway analyses with the miRNA expression correlations and predicted targets was made by matching the top-60 enriched miRNAs in ASC-EVs with predicted mRNA targets in miRWalk (Suppl data 2 , complete list of nominally significant genes, p-value < 0.05 for each miRNA) and subsequent GO enrichment analyses showed a preponderance for mRNAs affected by miR-1290, miR23/27/24 cluster and the miR-15/107 family with no less than 15,870 mRNAs to be targeted by those enriched ASC-EVs-derived miRNAs.

Three MR models (IVW, weighted median, and GSMR) demonstrated nominally significant ( p < 0.05) causal effect of IPF on CAD, with the estimated liability-scale odds ratios (ORs) ranging from 1.08 to 1.38 (Table 2 ).

Association analysis was performed on these 7,369 transcripts which resulted in the identification of 461 FDR-significant GA-related transcripts (1,611 nominally significant transcripts; nominal p -value < 0.05).

We took into account only those genes that reached significance (nominally significant p -value < 0.05).