“nominally significant”

Predicted impact of ASC-EV-derived miRNAs on cellular processes The enrichment pathway analyses with the miRNA expression correlations and predicted targets was made by matching the top-60 enriched miRNAs in ASC-EVs with predicted mRNA targets in miRWalk (Suppl data 2 , complete list of nominally significant genes, p-value < 0.05 for each miRNA) and subsequent GO enrichment analyses showed a preponderance for mRNAs affected by miR-1290, miR23/27/24 cluster and the miR-15/107 family with no less than 15,870 mRNAs to be targeted by those enriched ASC-EVs-derived miRNAs.

For each gene, the genotype score for a randomly chosen common SNP (common variant genotype score, CVGS) was regressed on the unweighted sums of genotype scores for all rare SNPs in the gene (sum of rare variant genotype scores, SRVGS), and the frequency of nominally significant ( P < 0.05) regressions was recorded.

Association analysis was performed on these 7,369 transcripts which resulted in the identification of 461 FDR-significant GA-related transcripts (1,611 nominally significant transcripts; nominal p -value < 0.05).

Regarding descriptive statistics on rumination, gender, age, lifetime psychiatric problems, and present somatic disorders, Supplementary Table 1 shows that except for frequency of pain problems there are differences between the Budapest and Manchester subsamples in all variables at either a nominally significant ( p ≤ 0.05) or trend (0.05 < p ≤ 0.10) level.

Moreover, a nominally significant association threshold ( p < .05) was set in the replication stage to ensure that the overall significant association is robust across populations.

Our findings identified 50 plasma metabolites exhibiting nominally significant causal associations with ED ( P < 0.05).

For cross-ancestry comparison of significant hits in the discovery phase, a nominally significant threshold of P < 0.05 was considered significant.

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

Among 41 edges showing nominally significant group differences, one edge remained significant after correction for multiple comparisons (p < .05, adjusted using FDR).

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).

All results that are nominally significant at P < 0.05 with no adjustment for the effects of multiple tests or comparisons are presented.

Ingenuity pathway analysis We utilized QIAGEN’s Ingenuity Pathway Analysis software 39 to determine potential upstream regulators and downstream biological functions of keloid-associated predicted gene expression, using nominally significant ( p < 0.05) GPGE results across the four meta-analyses.

We find that all 36 were at least nominally significant and 32 codes have a p -value < 0.05 and, after multiple testing correction, 25 of 36 ICD10 codes are significant in both cohorts, thereby indicating the consistency of our findings.

Subsequently, we included all nominally significant determinants ( P < .05) as covariates in the multivariable models in each cohort independent of their effect estimates.

This CpG was nominally significant ( p < 0.05) in both Non-Hispanic White (∆DNAm = 1.5%, p = 6.38 × 10 −7 ) and Hispanic groups (∆DNAm = 1.1%, p = 0.008), but not in African American group.

Associations were deemed nominally significant at P < 0.05 in light of the moderate eQTL sample size.

More interestingly, we found the amount of insoluble APOE in FA fractions was strongly correlated with the maximum RT-QuIC ThT signals (OR = 1.09, p < 0.001), with a similar, though slightly weaker, nominally significant ( p < 0.05) association observed when adjusting for a number of APOE4 alleles (OR = 1.07, p = 0.01, Table 6 ).

However, each of the experiments revealed 100–400 genes with nominally significant changes in gene expression ( p < 0.05).

However, the effects reported in Bäumler’s study [ 3 ] were small and nominally significant (two-tailed p < .05) only for bulkiness.

A nominally significant association was observed between survival and the DPP4 enzymatic activity at day 1 (p ≤ 0.05), with a higher DPP4 enzymatic activity being associated with an increase in survival.

List of all FDR significant DE ncRNAs at FDR < 0.05 as well as the nominally significant DE ncRNAs (P < 0.05) for both ileal and rectal biopsies are provided in Additional file 4 : Table S3.

To further enrich for putatively mechanistic relationships that are perturbed in disease, we specifically focused on the subset of associations that were nominally significant ( p <0.05) and in the same direction when considering raw metabolite and species abundances from non-IBD controls only (we refer to these associations as “confirmed in controls”).

Similar tendency was observed in nominally significant bins (p-value < 0.05).

Of the 21 variants, 6 were nominally significant (p < 0.05).