“nominally significant”

Among 41 edges showing nominally significant group differences, one edge remained significant after correction for multiple comparisons (p < .05, adjusted using FDR).

ROH hotspots contain genes with diverse functions Regarding the gene content of genomic segments co-localising with both high homozygosity regions and ROH hotspots (CHI4:42,552,375–48,378,207 bp), the functional enrichment analysis highlighted several gene ontology terms with nominally significant enrichment ( P -value < 0.05) (Additional file 7 : Table S5).

The resulting p -values were considered nominally significant at p < 0.05 level.

All results that are nominally significant at P < 0.05 with no adjustment for the effects of multiple tests or comparisons are presented.

Ingenuity pathway analysis We utilized QIAGEN’s Ingenuity Pathway Analysis software 39 to determine potential upstream regulators and downstream biological functions of keloid-associated predicted gene expression, using nominally significant ( p < 0.05) GPGE results across the four meta-analyses.

Subsequently, we included all nominally significant determinants ( P < .05) as covariates in the multivariable models in each cohort independent of their effect estimates.

We contrasted polygamous and monogamous evolutionary regimes at each age class and report comparisons both nominally significant ( P < 0.05) and significant after Bonferroni correction ( P < 0.01).

This CpG was nominally significant ( p < 0.05) in both Non-Hispanic White (∆DNAm = 1.5%, p = 6.38 × 10 −7 ) and Hispanic groups (∆DNAm = 1.1%, p = 0.008), but not in African American group.

Associations were deemed nominally significant at P < 0.05 in light of the moderate eQTL sample size.

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).

More interestingly, we found the amount of insoluble APOE in FA fractions was strongly correlated with the maximum RT-QuIC ThT signals (OR = 1.09, p < 0.001), with a similar, though slightly weaker, nominally significant ( p < 0.05) association observed when adjusting for a number of APOE4 alleles (OR = 1.07, p = 0.01, Table 6 ).

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

List of all FDR significant DE ncRNAs at FDR < 0.05 as well as the nominally significant DE ncRNAs (P < 0.05) for both ileal and rectal biopsies are provided in Additional file 4 : Table S3.

Similar tendency was observed in nominally significant bins (p-value < 0.05).

We find that all 36 were at least nominally significant and 32 codes have a p -value < 0.05 and, after multiple testing correction, 25 of 36 ICD10 codes are significant in both cohorts, thereby indicating the consistency of our findings.

Association analysis was performed on these 7,369 transcripts which resulted in the identification of 461 FDR-significant GA-related transcripts (1,611 nominally significant transcripts; nominal p -value < 0.05).

However, the effects reported in Bäumler’s study [ 3 ] were small and nominally significant (two-tailed p < .05) only for bulkiness.

Of the 21 variants, 6 were nominally significant (p < 0.05).

None of the five distinct significant SNPs that were listed in this study had a nominally significant association ( P < 0.05) with schizophrenia in the GWAS by Ripke et al . 38 We found no genetic correlation between syncope risk and schizophrenia ( Figure 3 ).

All significant (FDR<5%) and nominally significant ( p < 0.05) associations for all outcomes are shown in Tables S2 and S3 .

Furthermore, substantially more AAM signals showed at least nominally significant associations (GWAS P < 0.05) with relatively early (102, 31.1%) or relatively late facial hair (152, 46.3%) compared to ~16 expected by chance for each outcome (Supplementary Data 1 ).

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

Markers were included in the network if they showed a nominally significant association with GHQ (p < 0.05) in the linear regression analyses.

The only nominally significant ( p < 0.05) difference among the randomization groups was for height, which was highest in the metformin group.