“nominally significant”

A subset of 80/233 (34.3%) FDR significant associations also were nominally significant in at least one population of non-European ancestry ( p value <0.05; Supplementary Data 13 , 14 ).

We find that 2/6 nominally significant relationships show evidence of replication, with the same direction of effect ( P < 0.05 after Bonferroni correction, linear regressions).

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

One hundred sixty of 282 (56.73%) of nominally significant associations ( P < 0.05) were reproduced with the original effect direction.

Nominally significant results ( p < 0.05 in interaction tests and stratified genotypes analysis) were further pursued by applying the same Cox proportional hazards regression models to the FHS (incident AD) and ADNI data (MCI to AD conversion).

Where the linear dose term was nominally significant at P<0.05, we also used a complementary means of analysis to examine within-subject QTc effects.

When comparing these results to our previous endometrium microarray study ( Fung et al ., 2018 ), we find 75% of Bonferroni significant eQTLs identified by RNA-Seq were nominally significant ( P < 0.05) in the microarray data with ES highly correlated (R = 0.75).

The presented additional file 3 indicate the power to find nominally significant associations (p < 0.05) given analysis settings used for the estimation of effect sizes shown in Tables 1 and 2 .

Although this analysis did not yield any significant genes after multiple testing correction, 15 genes were nominally significant ( p < 0.05), corresponding to a 2-fold enrichment with respect to the null hypothesis (Supplementary Fig. 7c ).

3.2 Within-group differences in rsFC of subregions Positive rsFC of amygdala subregions was observed using the nominally significant threshold ( p < 0.05) within the two groups.

For nominally significant interactions (unadjusted p < 0.05), we reported estimates reflecting differences in treatment responses between clinical subgroups (Table 3 ).

as potential biomarkers, two were not identified in our study, one (Hemoglobin subunit β) was found to be nominally significant ( p < 0.05) but did not pass adjustment for multiple testing, and the remaining five were identified but not found to be significant in our study.

Across the 49 discovery lipid hits, 20 were also mapped by the Ottensmann panel; of those, 18 (90%) showed a concordant direction of effect in the Finnish sample, and eight (40%) were nominally significant ( p < 0.05) for an MDD association ( Figure S4 ).

Examining the 453 nominally significant ( p < 0.05) upregulated trans-eGenes, we found that they were significantly enriched for multiple pathways critical to mucin production and secretion, including IRE1-mediated unfolded protein response , protein N-linked glycosylation , and ER to Golgi vesicle mediated transport , Golgi subcompartment , as well as in marker genes of mucus secretory cells determined from single cell RNA-sequencing (scRNA-seq) data 30 (Fig. 4e , Supplementary Data 7 ).

To facilitate visual comparison of effect sizes across loci, a forest plot summarising the age- and sex-adjusted odds ratios and 95% confidence intervals for polymorphisms with nominally significant associations (p < 0.05) is provided in Figure 2 .

We did, however, observe nominally significant correlations ( p -value < 0.05) between other pairs of tested neurodegenerative diseases, except for FTD, for which there were no nominally significant correlations (Supplementary Table 1 ).

Analysis limited to the younger group identified 665 nominally significant ( p < 0.05) autosomal genes, with only three genes achieving FDR significance.

In summary, prior to correction for multiple testing, one nominally significant ( p < 0.05) finding in the alpha-2-adrenergic receptor 2A gene ( ADRA2A ) was noted.

In addition, the ovarian cancer patients had a nominally significant decrease in the number of 12 and 22 genotype carriers compared to the controls (p = 0.05) suggesting that the duplication may be protective for the disease with an odds ratio of 0.72 (95% CI, 0.53–0.99).

We defined significant novel associations as those that were at least nominally significant in replication (P<0.05) with consistent direction of effect and had an overall P < 5×10 −8 (genome-wide significance) in the discovery and replication cohorts combined.

However, 38,797 probes were nominally significant (at p < 0.05) in the caudate and 35,622 probes in the ACC - Fig. 1 and Supplementary File 1 .

Although with small effects (absolute delta betas < 5%), two CpGs in KTN1 were nominally significant (cg14002714 and cg21059882; p < 0.05).

Genes with nominally significant differential expression ( p < 0.05) between the chronic and acute time points in untreated or P. gingivalis - or C. pneumoniae -treated ApoE -/- mice are tabulated in Figure 3 .

The resulting p -values were considered nominally significant at p < 0.05.

In our phenome-wide analysis, we identified a total of 179 nominally significant associations ( p < 0.05; Fig. 1 , Supplemental Table 5 ) with respect to TTR Ala81Thr, His90Asn, and Val122Ile mutations (60, 54, and 65 associations, respectively).