“nominally significant”

In contrast, the probabilities of transitioning from other PL states to PL state 3 were all increased, with the transition from PL state 4 to PL state 3 also showing a nominally significant difference (uncorrected p = 0.0376, Cohen’s d = 0.5201).

Longitudinal stratification of the CIPN phenotypes to examine links for neuropathy, identified nominally significant protective associations with the GSTM* null allele ( p -value = 0.038, OR = 0.55) and the presence of pain at month 2 of treatment, as well as a risk factor for pain related month 2 of treatment for individuals with the GSTT1* null allele ( p -value = 0.030, OR = 1.64).

When tested individually, both di- and tetranucleotides showed at least nominally significant signals (two-sided z -proportion test P = 0.038 and P = 3.7 × 10 –38 , respectively), but trinucleotides did not ( P = 0.95).

MR pleiotropy residual sum and outlier (MR-PRESSO) test identified 5 outliers for IBD, 1 for RA and 2 outliers for vitiligo ( Table S10 ), whereas exclusion resulted in a nominally significant association for vitiligo (OR, 95% CI: 0.827, 0.691–0.989), p -value = 0.038; Figure 4 a).

Additional sensitivity analyses showed that the cML-MA-BIC-DP method (OR 0.60, 95% CI 0.53–0.69, p = 3.85 × 10 −11 ) yielded a similar result to IVW and weighted median methods ( Table 5 ), while the association from MR-APSS method was nominally significant (OR 0.20, 95% CI 0.05–0.92, p = 0.038) ( Table 5 ; Supplementary Figure S2 ).

Among diabetic patients, a nominally significant difference in unadjusted event rates was observed (12% vs. 35%, p = 0.038), though this exploratory subgroup analysis requires cautious interpretation given the small sample and absence of adjustment for confounders. 4.1.

At a threshold of FIS ≥0.7, SERPING1 variant carriers had a nominally significant increased risk of NCEIS (HR, 3.29; 95% CI, 1.06-10.19; P = .039) and PAD (HR, 3.10; 95% CI, 1.29-7.45; P = .011), with the association for PAD remaining significant after Bonferroni correction ( Figure 2 C; supplemental Table 4 ).

Nominally significant positive associations were observed between the weighted PGS and maternal alcohol consumption at week 30 (ST17; beta = 0.067, se = 0.032, p = 0.039).

0.25), corresponding to a nominally significant association (OR = 1.68; 95% CI: 1.05–2.67; p = 0.039).

The difference in lymph node reduction between groups had nominally significant association in this exploratory analysis (p = 0.039, independent-samples t -test), with a moderate-to-large effect size (Cohen’s d = 0.71) ( Figure 2 ).

Assessment for significance of an SOD2 (# Ala16 alleles)-by-deployment interaction term (adjusted for both components of the interaction) to evaluate for effect modification by deployment was nominally significant, p = 0.039.

We further note that rs73404538 is nominally significant in the Sierra Leone susceptibility GWAS ( P = 0.039, OR = 0.71) and in a meta-analysis of the Nigeria and Sierra Leone susceptibility GWASs ( P = 0.021) with a concordant direction of effect (Extended Data Table 4 ).

For the OR, FA showed a nominally significant negative association at the uncorrected level (β = − 0.187, t (110) = −2.084, p =.039), but this did not survive FDR correction (FDR adjusted q = 0.118).

Progression-free survival (PFS) was also significant ( p = 6.730 × 10 −3 ; q = 0.0143), disease-specific survival (DSS) was nominally significant but borderline after FDR correction ( p = 0.0399; q = 0.0532), and disease-free survival (DFS) was not significant ( p = 0.0903; q = 0.0903) ( Figure 4 , Table S3 ).

In the GAMs analysis, two variables showed nominally significant effects: baseline PNS index ( P = 0.040, b splin e 1 = − 0.942 ) and gender ( P = 0.028, coefficient = − 0.1332 ), with partial effects illustrated in Figure 5 and full results reported in the Supplementary Materials ( Supplementary data online , Table S5 , Supplementary data online , Figure S10 ).

PFDEA, PFNA and PFUA concentrations were found to be nominally significantly associated with a higher number of gestational weeks at delivery (PFDEA: β 0.36, 95% CI 0.03–0.69, p = 0.04; PFNA: β 0.34, 95%CI 0.01–0.66, p = 0.04; PFUA: β 0.34, 95% CI 0.05–0.63, p = 0.04) but were not robust to multiple testing correction ( Table 4 ).

8 In the multivariable Cox model reported by Ruhwedel et al., the overall effect of primary tumor location was not statistically significant ( p = .11), but there was a nominally significant association for shorter OS in patients with pancreatic versus gastrointestinal NETs during [ 177 Lu]Lu‐edotreotide therapy ( p = .04). 33 However, there are prognostic differences between NETs of different origin, depending on the aggressiveness of disease. 44 , 45 Overall, our findin

In the Phase 2 HART trial, the 45 mg bid (twice daily) dose showed a nominally significant benefit to TMS vs. placebo (Δ = −2.8, p = 0.04), particularly in hand movements (Δ = −0.93, p = 0.02) and gait and balance (Δ = −0.48, p = 0.04) [ 150 ].

MiR‐223‐3p showed a significant AUEC over 0.67 days for IFNβ‐1a when the miRNA returned to baseline ( p = 0.015), and a nominally significant AUEC for pegIFNβ‐1a over 13 days ( p = 0.04).

When examining all subjects, nominally significant associations between carrier-status and remission (p = 0.04) and PSS-14 scores (p = 0.04) were observed after correcting for treatment arm.

Longitudinal change in total recall performance was nominally significant ( p = 0.04) between the PiB + and PiB − groups, and total recall at baseline was also significantly different between groups ( p < 0.01) indicating, as expected, a more overt cognitive decline was present in the individuals with positive PiB scans.

For example, in LiAc, GxE was seen for all reporters in that BY showed no significant change in UPS activity compared with SC for any reporter, while RM showed at least nominally significant reductions for all reporters ( t -test for effect of environment per strain, P ≤ 0.04).

When analyzing the time to gastrostomy based on the initial randomization group, the survival curves differed ( Figure 3 ) and Cox regression indicated a nominally significant difference (Likelihood Ratio Test, p = 0.040).

We did not find a significant association between severity of endometriosis and self-reported coeliac disease, neither did we find an association with self-reported lactose intolerance. The endometriosis PGS was not associated with defaecation pattern regularity ( P FDR = 1.00), though it did associate (nominally significant) with some of the gastrointestinal symptoms, i.e. abdominal pain (OR = 1.22, 95% CI = 1.01–1.47, p = 0.04, P FDR = 0.55) and pain during food intake (OR = 2.60, 95% CI = 1.28–5.29, p = 0.01, P FDR = 0.09).

ANN NEUROL 2025;98:1027–1043 Although WMH volume showed a nominally significant association with hippocampal volume ( p = 0.04) in the P‐tau181‐based BM‐CTL group, this did not remain significant after correction for multiple comparisons.