“nominally significant”

Nominally significant associations between left amygdala MD and attentiveness to the caregiver did not survive correction for multiple comparisons (β (SE) = − 0.20 (0.10), raw p-value = 0.044, p-value adjusted = 0.400).

The GWA of mtDNA-CN based on CHARGE Consortium and UK Biobank cohorts ( n = 24,622; median follow-up 4318 days) found a nominally significant association between mtDNA haplotypes and the overall non-external mortality ( p = 0.044) [ 31 ].

In contrast, while the CN model showed a nominally significant interaction (p = 0.044), the non-significant slope in the LL/LD subgroup (β = 0.191, p = 0.153) fails to support robust moderation.

Nominally significant genetic correlations were observed between RA and CAD ( r g = 0.05, P = 0.044), and between T1D and CAD ( r g = 0.08, P = 0.034) (Fig. 2 a and Supplementary Table S3 ).

Water intake was also found to have a nominally significant inverse association with ON risk (OR = 0.19, 95% CI: 0.04–0.96, P = .045); However, this association did not remain statistically significant following FDR correction (FDR-adjusted P = .054).

In this sensitivity analysis, the mADF group showed a nominally significant association with lower REE values compared with the MedDiet group ( p = 0.045).

A large number of preplanned exploratory analyses were performed in the PLATO trial, and a nominally significant treatment interaction for geographic region ( P = 0.045) was observed.

ALS had nominally significant global genetic correlations with schizophrenia (p = 0.045), PD (p = 0.013), and AD (p = 0.006); no other bivariate genome-wide correlations were statistically significant (see Figure 2 ).

The exploratory SCN1A + subgroup analysis (79% of study participants) showed a nominally significant reduction from baseline in convulsive seizure frequency ( p = .045) with soticlestat versus placebo.

However, a nominally significant interaction was observed for sex ( P = 0.045), suggesting that females may have higher odds of self-harm ideation than males across alcohol consumption levels, despite similar J-shaped patterns (Supplementary Fig. 4 ).

We observed nominally significant differences in PRS distributions, with younger individuals (< 40 years) having higher PRS (p = 0.045) compared to older individuals, and carriers of rare variants having lower PRS compared to non-carriers (p = 0.037).

Simple t -tests contrasting the trait values of those recombinants subjected to WGS- or MSG-based genotyping were not significant in most cases ( p > 0.1 for lobe area, height, width, height-to-width ratio, PC2, and PC3), and only nominally significant in one case that does not survive correction for multiple testing ( p = 0.045 for PC1).

One additional interaction was nominally significant before FDR correction but did not survive multiple testing adjustment: CETP –macronutrient interaction with LDL-C (unadjusted p = 0.0454, FDR p = 0.1086).

For ΔDSL, the interaction term was nominally significant (β = −0.605, 95% CI −1.198 to −0.012; p = 0.046); because this analysis was exploratory and the study was not powered for interaction testing, this finding was interpreted cautiously and not taken as evidence of a confirmed modifying effect.

Subsequently, we used a t ‐test to compare the ME between AD+P and AD−P samples, identifying six nominally significant modules (darkgreen: N = 1023 probes, p = 0.046; firebrick4: N = 122 probes, p = 0.025; darkseagreen3: N = 105 probes, p = .012; magenta: N = 6368 probes, p = 0.030; grey60: N = 1830, p = 0.018; greenyellow: N = 5512 probes, p = 0.045).

Look-up of genes associated with ectopic pregnancy in previous literature ( ADGRD1 ( GPR113 ), VEGFA, IL8 , IL6 , ESR1 , and EGFR ) revealed that none of them passed the Bonferroni correction threshold and only GPR113 (also known as ADGRD1 ) and ESR1 were nominally significant ( P = 0.046 and P = 0.044, respectively).

The interaction between ancestry and WHR for HbA1c was nominally significant for EA ( β = 6.42 ± 3.22, p = 0.046) and SA ( β = 3.05 ± 1.33, p = 0.02) (Table S10 ).

3.5 Sleep disturbance score and rate of brain Aβ accumulation After Bonferroni correction for multiple comparisons, a nominally significant three‐way interaction was observed among moderate/severe sleep disturbance, APOE ε4 carriage, and time (β = 2.35 ± 1.17, P = 0.046), with respect to rate of brain Aβ accumulation.

The GGN microsatellite in exon 1 of the AR gene showed modest nominally significant associations between a dichotomous (homozygous major allele GGN 23 carried by 70% of individuals vs rest) measure and two outcomes: child IQ (r = −0.104, p = 0.046) and anxiety symptoms (r = 0.096, p = 0.040).

While the test of homogeneity was only nominally significant ( p = 0.046), six of the seven ORs were greater than one.

In the fully adjusted model including Total WMH and CMC, standardized β coefficients were −0.005 (95% CI, −0.064 to 0.054; p = 0.87) for reaction time, −0.007 (95% CI, −0.065 to 0.052; p = 0.82) for Trail Making Test–B, −0.058 (95% CI, −0.116 to −0.001; p = 0.046, nominally significant) for fluid intelligence, and −0.019 (95% CI, −0.110 to 0.072; p = 0.68) for digit span.

For the APD traits, only the DRD2 TaqID SNP showed a nominally significant association (p = 0.046) which did not remain significant after correcting for multiple comparisons.

Using human genetic data from the 1000 Genomes Project, we calculated the DH value for the NOVA1 locus, which was nominally significant at p = 0.046.

The only nominally significant interaction was with active smoking (HP×active smoking OR 0.65, p=0.046; table 3 ).

In addition, a positive correlation between symptom severity and physical activity levels was nominally significant (ρ = 0.32, p = 0.046, q = 0.514) ( Figure 2 A, Supplemental Table S3 ).