“nominally significant”

In addition, a positive correlation between symptom severity and physical activity levels was nominally significant (ρ = 0.32, p = 0.046, q = 0.514) ( Figure 2 A, Supplemental Table S3 ).

For the overall participants, the plasma concentrations of Aβ42 were nominally significant for subjects carrying the rs1784933 G allele having a lower level than those without the G allele ( p = 0.046).

Overall, a total of thirty-one SNPs were nominally significant (2.34 × 10 −4 < p < 4.66 × 10 −2 ) in this single SNP analysis.

No PMO were significant predictors of pre-weaning mortality rate, although 2′FL concentration was nominally significant prior to FDR correction ( P = 0.0466), with an increase in 2′FL concentration associated with a decrease in pre-weaning mortality rate ( R 2 = 0.332; β = −0.510).

Although a nominally significant difference was found between Grade II and Grade IV ( p = 0.0466), this did not remain significant after Bonferroni correction.

In the CHARGE-SpiroMeta cohort, rs4820911 and rs11030451 were nominally significant but both with an effect in the opposite direction of Lifelines (rs4820911:G, β ( se ): −14.3 (7.2) mL·y −1 , p=0.047; and rs11030451:C, β ( se ): 7.4 (3.6) mL·y −1 , p=0.04) ( supplementary table S2 ).

Notably, several KEGG “disease” or host-associated annotation categories (e.g., toxoplasmosis, small cell lung cancer, p53 signaling, influenza A, viral myocarditis, colorectal cancer) appeared among nominally significant features (all P ≈ 0.047) but displayed effect sizes close to zero.

The superiority of the combination versus group B was nominally significant ( P = .047; 2-tailed t -test), but not versus the other groups (A versus C: P = .074; A versus D: P = .5).

This was replicated in the sensitivity cohort, although age at menopause was nominally significant ( P = 0.047) (Additional file 1 : Table S6).

Comparing MDD responders and non-responders, nominally significant group by time interactions were observed for the nodal efficiency of left amygdala ( χ 2 = 3.394, p = 0.047; Cohen’s d = 0.585; 95% CI, 0.01–1.16) and λ ( χ 2 = 6.652, p = 0.009; Cohen’s d = −0.680; 95% CI, −1.19. to −0.16) (Supplementary Fig. 2a, b ).

We observed greater within-pair difference in DNA methylation in cancer-discordant twins compared to healthy twins, with nominally significant effects at cg27094856 in AXL (healthy median 0.78 % vs. cancer median 1.44 %, P = 0.047), and near significant effects at cg02444695 near SASH1 (healthy median 1.48 % vs. cancer median 2.32 %, P = 0.091).

Repeated-measures ANOVA showed a nominally significant effect of time (F(3, 213) = 2.699, p = 0.047, η p 2 = 0.037), although the Greenhouse–Geisser-corrected result was no longer statistically significant ( p = 0.052).

CYP2C19 phenotypes showed a nominally significant association with TRD (χ 2 = 9.64, p = 0.047, Table 2 and Supplementary Table S6 ) in the whole sample, but not when limiting the analysis to patients treated with antidepressants with clinical annotations for CYP2C19 reported in ClinPGX ( Supplementary Table S7 ).

An expanded covariate-adjusted sensitivity analysis ( Supplementary Table S4 ) in which the BIS post-intervention score was regressed on Group with baseline BIS, age, sex, and baseline SIQ-JR, FASM, CES-DC, and AQ as covariates yielded a nominally significant group coefficient (B = −2.908, SE = 1.447, p = 0.047, R 2 = 0.564); however, this finding does not eliminate the possibility of confounding by indication, as the clinical assignment variables most likely to produce confounding were not available in the retrospective dataset.

The previously identified GWAS HV SNP (rs6581612) and the candidate BDNF SNP (rs6265) were nominally significant ( p = 0.047 and p = 0.041 respectively).

In addition, IL-5 exhibited a nominally significant associations with right ventricular function, particularly with right ventricular stroke volume (RVSV; OR = 2.4489, 95% CI = 1.0113–5.9302, p = 0.0472, adjusted p = 0.461).

For EPB41L2 , although the IVW estimate was nonsignificant ( P > 0.05), the weighted median method yielded a nominally significant protective effect (odds ratio = 0.601, 95% confidence interval: 0.646–0.777, weighted median P = 0.048), providing suggestive evidence for a causal role.

Specifically, while the miR-499 rs3746444 recessive model showed a nominally significant association ( P = 0.048), this association was no longer significant after Bonferroni correction. 4 Discussion MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression and tumorigenesis, acting as either oncogenes or tumor suppressors depending on the cellular context ( 16 ).

Neither childhood trauma nor CES score alone accounted for unique variance in ACC volume (childhood trauma: β = − 0.15, t = − 1.42, n.s.; CES: β = − 0.20, t = − 1.85, n.s.); however, the simultaneous regression model was nominally significant (adjusted R 2 = 0.05, F(2,84) = 3.2, p < 0.048).

The univariable MR estimates were nominally significant for the effect of genetically high IL-2ra (IVW β = 0.001; 95% CI, 8.7 × 10 − 6 to 0.002; P = 0.048) or IL-4 (IVW β = 0.003; 95% CI, 0.001 to 0.005; P = 0.003) or monokine induced by gamma interferon (MIG) (IVW β = 0.002; 95% CI, 0.0008 to 0.003; P = 0.001) or MIP1b (IVW β = 0.002; 95% CI, 0.0007 to 0.003; P = 0.003) with eGFRcrea, also indicating the protective role of these systemic inflammatory regulators on kidney function.

Overall, at 6 months, the risk of the composite vascular endpoint (vascular death, myocardial infarction, or stroke) did not differ between treatment groups ( p = 0.52), while analysis of functional outcome (shift in modified Rankin Scale (mRS) using ordinal logistic regression) suggested a nominally significant ( p = 0.048) higher risk of poor outcome in the candesartan group (not significant after multiple testing correction at p ≤ 0.025).

A nominally significant difference in LOS was observed in the humerus shaft subgroup (mean 19.8 ± 9.1 vs. 11.0 ± 14.2 days, p = 0.048); however, this comparison is based on only four patients with available LOS data and cannot be considered a meaningful finding.

In Model 2, dietary zinc density showed a nominally significant positive association with cfPWV (B = 0.271; 95% CI: 0.0018 to 0.540; p = 0.048).

A nominally significant correlation was noted between adjusted PAT and heart failure (genetic correlation [rG]=0.36, standard error [se]=0.18, P =0.048).

Causal effect of OSA on LSB/PA IVW analysis revealed a nominally significant association between OSA and MVPA (OR = 0.97, 95% CI = 0.94–0.99, p = 0.048).