“nominally significant”

Causal effects of SGLT2 inhibition on gut microbiota and metabolites The IVW method revealed 152 nominally significant associations (p < 0.05) between SGLT2 inhibition and gut microbiota, 173 nominal associations with 249 circulating metabolites, and 220 nominal associations with 486 metabolites ( Figures 3 – 5 ; Supplementary Table S4 ). 3.4.

Overall, 11/17 (65%) associations were nominally significant at p<0.05, 9/17 (53%) at p<0.001.

Gene-Level Enrichment Analysis via MAGMA Using the FUMA platform with MAGMA for gene-based analysis, we identified 3727 nominally significant genes (P < 0.05).

The input list of gene IDs was selected based on proximity to the CpGs with consistent and nominally significant (p < 0.05) estimates in all three models.

Examining genes nominally significant ( p -value < 0.05) in only one myocardial layer indicates distinct regional responses.

Furthermore, for the single variants within these genes that were nominally significant ( p <0.05) in the FinnDiane WES/WGS meta-analysis, we tested for replication in the FinnDiane, THL Biobank, FinnGen GWAS and TOPMed WGS data.

At nominally significant levels ( p < 0.05) for both threshold levels, HVEM (herpesvirus entry mediator) on naive CD8 + T cells (MFI) was suggested as a protective factor for NT1.

In addition, a nominally significant difference was found for the neuroendocrine parameters stress CORT and increase in CORT as measured in the HPA-RT in males (p < 0.05), but not females.

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

Of the 1,291 adult BMI variants compared, 395 variants (31%) were nominally significant ( p < 0.05) and 949 (74%) displayed directionally consistent associations with childhood BMI, which was far greater than would be expected by chance ( p < 0.001) ( Table S6 ).

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

Among these, all genes met FDR <0.05 in Group 1, 563 of 585 in Group 2, and none in the lineage-balanced Group 3, though all remained nominally significant ( p < 0.05).

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

A FDR-adjusted P value < 0.05 was considered statistically significant; unadjusted P value < 0.05 was considered nominally significant and unadjusted P value = 0.05 was considered borderline significant.

Results from PrediXcan 30 (in blood) supported our hypothesis that parents would have higher predicted gene expression than their children when testing dominant and recessive DD genes containing putatively damaging PTVs, but this result was only nominally significant and did not pass multiple testing correction ( p < 0.05) (Supplementary Fig. 9 ).

Among the 22 candidate SNPs evaluated, two imputed variants showed nominally significant association (p < 0.05) with lymphoma-specific death: rs1801131 in MTHFR (HR = 0.69, 95% CI 0.49-0.97, p = 0.03) and rs2069762 in IL2 (HR = 0.63, 95% CI 0.43-0.92, p = 0.02; Table 4 ). rs1801131 was also associated with lymphoma progression (HR = 0.59, 95% CI 0.45-0.77, p = 0.0001).

In addition, 26 dSVs and 51 vSVs showed nominally significant heritability ( P < 0.05), with an average h 2 of 0.28 and 0.41, respectively (Supplementary Tables 4 and 5 ).

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

Genes showing nominally significant correlations ( P < 0.05) were considered behavior-associated candidates in this exploratory analysis.

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

Covariate main effects were retained if nominally significant at P < .05 in the global test of their effect on the mean of the multivariate endpoint.

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

The second analysis mirrored attempts to replicate the pattern previously suggested for multiple sclerosis, 13 – 16 that is, finding a nominally significant ( p < 0.05) excess of births in March, April, or May and/or a nominally significant ( p < 0.05) deficit in November, December, or January.

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.