“nominally significant”

All loci identified here were directionally consistent, nominally significant with “rapid3” and/or “CKDi25” (one-sided P<0.05) and two were genome-wide significant for rapid3 or CKDi25 ( UMOD - PDILT , PRKAG2 - GALNTL5 ).

35 Identification of Differentially Methylated Regions Differentially methylated regions (DMRs) were defined as more than 1 consecutive DNA methylation site spaced less than 1500 base pairs apart, with a nominally significant ( P < .05) main effect of genotype, and each with the same direction of effect.

This screening identified 64 genes with a nominally significant causal effect on BMI (IVW P < 0.05) and 92 genes with a significant effect on gout.

Comparison of miRNA profiles between low- and high-risk tumors identified multiple candidate miRNAs with nominally significant differential expression ( p < 0.05).

Overall, 11/17 (65%) associations were nominally significant at p<0.05, 9/17 (53%) at p<0.001.

In patients with moderate or severe DED ( n = 53), PL9643 treatment demonstrated either nominally significant ( P < 0.05) or trending ( P < 0.1) improvement over placebo in mean change from baseline at week 12/day 85 in several sign endpoints, including fluorescein staining in inferior, superior, corneal sum, and total sum regions; Lissamine Green staining in temporal, nasal, conjunctival sum, and total sum regions; and tear film breakup time.

Some nominally significant correlations (uncorrected p < 0.05) were also observed in AN and BN groups (details in the Online Supplementary Material, Tables S1-S3).

Clinical Characteristics of Patients with Upper-Limb Melanoma ( Table 4 ) As illustrated in Table 4 , when comparing nine melanoma patients with upper-limb tumors with the remaining 124 melanoma patients, the only nominally significant findings were a higher frequency of the CT heterozygous genotype (OR = 5.01, p = 0.050) and a lower frequency of the CC homozygous genotype (OR = 0.11, p = 0.040).

Of the 1,291 adult BMI variants compared, 395 variants (31%) were nominally significant ( p < 0.05) and 949 (74%) displayed directionally consistent associations with childhood BMI, which was far greater than would be expected by chance ( p < 0.001) ( Table S6 ).

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

This is a reflection of a significant skew in the 5hmC fold changes between iPSC and NSC cell lines ( Figure 2C ), with 53.8% of tested sites exhibiting negative FC (i.e., NSC hypo -hydroxymethylation), but increasing to 89.4% among nominally significant t-test results at p < 0.05 ( n = 3,837; none are epigenome-wide significant).

Gene-Level Enrichment Analysis via MAGMA Using the FUMA platform with MAGMA for gene-based analysis, we identified 3727 nominally significant genes (P < 0.05).

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

Of the remaining eight risk SNPs without significant signals, they found nine genes among four SNPs that were at least nominally significant ( P <0.05).

Causal effects of SGLT2 inhibition on gut microbiota and metabolites The IVW method revealed 152 nominally significant associations (p < 0.05) between SGLT2 inhibition and gut microbiota, 173 nominal associations with 249 circulating metabolites, and 220 nominal associations with 486 metabolites ( Figures 3 – 5 ; Supplementary Table S4 ). 3.4.

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

The input list of gene IDs was selected based on proximity to the CpGs with consistent and nominally significant (p < 0.05) estimates in all three models.

Results for the well-being score were all directionally consistent but none were nominally significant ( P < 0.05). 4. 2-sample MR with non-overlapping depression GWAS Using the PA and ST instruments identified in our MRLap analysis we provide further evidence for the role of PA in depression using the summary statistics from the Wray et al.

Nominally significant ( P <0.05) associations between PGS SCAD and headache were observed in the analyses of African‐ancestry individuals (N headache =179, N control =6817; OR, 1.22 [95% CI, 1.06–1.41]; P =6.94×10 −3 ) and South Asian–ancestry individuals (N headache =190, N control =6725; OR, =1.18 [95% CI, 1.02–1.37]; P =2.43×10 −2 ) (Figure [ B ]).

One hundred sixty of 282 (56.73%) of nominally significant associations ( P < 0.05) were reproduced with the original effect direction.

At nominally significant levels ( p < 0.05) for both threshold levels, HVEM (herpesvirus entry mediator) on naive CD8 + T cells (MFI) was suggested as a protective factor for NT1.

In addition, a nominally significant difference was found for the neuroendocrine parameters stress CORT and increase in CORT as measured in the HPA-RT in males (p < 0.05), but not females.

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.