“nominally significant”

In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant ( p < 0.05) CpGs under inactivation, but not among CpGs escaping inactivation.

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

Causal effects were considered nominally significant (suggestive) when the IVW p < 0.05 and sensitivity analyses revealed no contradictory findings.

Result Our study offers novel evidence supporting the existence of a brain-liver axis, initially identifying 66 associations with nominally significant IVW estimates (P < 0.05).

Moreover, we identified 834 variant-trait associations primarily driven by the inclusion of participants from non-EUR populations; these associations were not even nominally significant in the EUR group (P > 0.05, table S9 ).

We found that 18 of the 108 proteins investigated were influenced by storage time (Supplementary Table 1, nominally significant, p < 0.05), and one protein (Cancer antigen 125; CA-125 also known as Mucin 16) remained statistically significant after correction for testing of multiple hypotheses (Bonferroni, p < 0.05/108 = 4.6 × 10 − 4 ).

A list of observed DNA variants and their effect on the hepatic copper score is presented in Table 1 . The five nominally significant variations ( P ≤0.05) were genotyped in an independent cohort of 59 Labrador retrievers ( Table 1 ; Table S1 ).

Differential gene expression analyses of CD11b + cells in VAT and SAT from individuals with obesity revealed nominally significant differences in the gene expression profile (FDR p < 0.05, absolute fold change > 1.5; Figure 1A,B ).

Despite limited overlap at the single-metabolite level between the two overall OC outcomes, we observed greater concordance at the pathway level: among nominally significant pathways (raw p < 0.05), arginine and proline metabolism and beta-alanine metabolism overlapped across the two outcomes ( Figure 1 E; Supplementary Table S4 ).

We found that four SNPs showed nominally significant associations at P <0.05 for rs26232 ( C5orf30 ), rs2073838 ( SLC22A4 ), rs11676922 ( AFF3 ), and rs7528684 ( FCRL3 ).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

A nominally significant association was observed between survival and the DPP4 enzymatic activity at day 1 (p ≤ 0.05), with a higher DPP4 enzymatic activity being associated with an increase in survival.

Although there was a nominally significant main effect of instruction, t (25.96) = 2.09, p = .05, there were no significant interactions involving instructions.

In the hDRG, hPEP.PIEZOh, hNP1, and hTRPM8 were nominally significant ( P < 0.05) cell types among females, and hPEP.TRPV1/A1.2, hAδ.LTMR, and hTRPM8 were nominally significant among males, though none of these cell types was significantly enriched after correction for multiple testing ( Supplemental Figure 1B and Supplemental Table 12 ).

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

In terms of the latter aspect, these four genes are indeed significant as all of them achieved nominally significant (p < 0.05) or marginally significant (p < 0.10) p values in our discovery and replication datasets.

When relative change from baseline in the various iron indices were analyzed using the ANCOVA model, with additional adjustments for study treatment and baseline hs-CRP, nominally significant treatment effects were seen for TIBC, transferrin, soluble transferrin receptor, and hepcidin (each P < 0.05; Table 2 ).

The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.

In total, 28 genes in the European-American sample and ten genes in the African-American sample were nominally significant (i.e., the observed test statistic differed from neutral expectations at p < 0.05) in one or more tests of the allele frequency distribution ( Figure 1 ).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

In addition, there was substantial enrichment of nominally significant associations ( p <0.05) among disease SNPs.

(i) The MR results using the Wald ratio or IVW methods show a nominally significant association with LUAD or LUSC risk ( P value < 0.05).

For this purpose, we extracted information on CpGs from each study that met methylome-wide significance as defined by that study’s criterion (e.g., Bonferroni, false discovery rate or FDR) or were nominally significant (p < 0.05).