“nominally significant”

In addition, 26 dSVs and 51 vSVs showed nominally significant heritability ( P < 0.05), with an average h 2 of 0.28 and 0.41, respectively (Supplementary Tables 4 and 5 ).

For replication, we externally tested 221 nominally significant associations (p<0.05) in an independent cohort from FinnGen.

Specifically, we identified a total of 169 nominally significant enriched terms ( p -value < 0.05 and FDR < 0.2), which represent a medium-confidence set, including a subset of 37 high-confidence terms that passed multiple test correction with an FDR of <0.05 ( Figure 3 ).

While none of the GO terms from the trio univariate GSEA met the FDR significance threshold, nominally significant (p < 0.05) pathways suggest some overlap with Cohort 1 results, including neuron recognition , cerebral cortex cell migration and axonal fasciculation and GO terms related to.

Moreover, the p -value for rs359240 in the PC-UKB sample was nominally significant ( p < 0.05).

A nominally significant association was observed between survival and the DPP4 enzymatic activity at day 1 (p<0.05), with a higher DPP4 activity being associated with an increase in survival.

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

Variable Selection Based on linear mixed models including the factors of time, age at enrollment, sex, and stimulus version, 23 speech variables from the picture description task showed nominally significant ( P < 0.05) effects of time at the group level.

For each refitted model, the fixed-effect estimate of the group-by-time interaction was extracted, and summary metrics were computed, including the range and mean of the estimated effects (β), the mean p -value, and the number of iterations in which the effect remained nominally significant ( p < .05).

Of these, 10 had significantly different effect sizes ( p -value < 7.8 × 10 −4 , Bonferroni correction for 64 variants) and 22 were nominally significant ( p -value < 0.05).

Differential methylation analysis identified 6095 nominally significant differentially methylated CpG sites (DMCs; p < 0.05, log fold-change > 0.1), associated with 2935 unique genes.

In the combined analysis, genetically predicted levels of 123 proteins were nominally significant associated with melanoma ( P < 0.05; Supplementary Data 5 ).

Nominally significant differences (p <0.05) were detected in MCV and MCH within males.

CNTNAP2 , COMT , DBH , DCDC2 - KIAA0319 , DRD2 , DYX1C1 , and FOXP2 had nominally significant results (uncorrected P < 0.05) for multiple SNPs in the CLDRC.

A FDR-adjusted P value < 0.05 was considered statistically significant; unadjusted P value < 0.05 was considered nominally significant and unadjusted P value = 0.05 was considered borderline significant.

Tier A molecules represented stringent, nominally significant (p < 0.05) miRNAs generated from RNA-Seq quantification that also showed a strong trend (p < 0.10) and directionally consistent changes in the microarray experiments.

We found 99.3% (5442/5478) of the FDR significant associations also had a nominally significant ( p ≤ 0.05) association in the Spearman rank test (Fig.

Among female-specific fertility traits, LDSC identified nominally significant ( P < 0.05) r g between increased MPB severity and fewer number of live births ( r g = −0.06, SE = 0.02) and increased age of first birth ( r g = 0.04, SE = 0.02) (Table 1 ), suggesting shared genetic risk.

Further, there were significant correlations between the number of nominally significant (p<0.05) MPRA variants identified for a gene and that gene’s local eQTL LOD score (rho = 0.12, p=0.003) and its absolute eQTL effect size (rho = 0.14, p=3e-5).

To evaluate whether there were differences in association strengths between PRSs for specific phenotypic categories, we regressed the effect sizes or ORs of all nominally significant (p < 0.05) PheWAS associations of one PRS against the other with a fixed intercept at zero for each category and then performed one-sample t tests of the resultant slopes against a value of 1.

Of those, 38,776 (95%) showed the same direction of effect, 33,128 (81%) also had a nominally significant p value ( p < 0.05), and 25,544 (63%) had an FDR-adjusted p < 0.05 in the BLUEPRINT data (Fig. 1b , Supplementary Data 1 ).

Another NASH CRN study also found nominally significant ( P < 0.05) associations between PNPLA3 genotype and fibrosis or lobular inflammation ( 57 ).

Furthermore, for the single variants within these genes that were nominally significant ( p <0.05) in the FinnDiane WES/WGS meta-analysis, we tested for replication in the FinnDiane, THL Biobank, FinnGen GWAS and TOPMed WGS data.

Psychometric Architecture of Cognitive Constructs: Principal Components Analysis Twenty cognitive subtests with nominally significant ( P < .05) baseline group differences were selected for PCA.

Although 75 proteins showed nominally significant abundance differences ( p ≤ 0.05), all corresponding q‐values were 0.99, indicating no statistically robust differences in abundance between PEA and VC at 36 h.