“nominally significant”

Psychometric Architecture of Cognitive Constructs: Principal Components Analysis Twenty cognitive subtests with nominally significant ( P < .05) baseline group differences were selected for PCA.

Multivariable modelling and the relations between predictor variables All predictor variables having shown nominally significant (p < 0.05) effects on hand preference in univariable testing (i.e. all but maternal smoking) were then included in the multivariable analysis, using general linear modelling (Methods), with hand preference as the dependent variable.

Overall, 35 of the 87 (40.2%) meta-analyses reported nominally significant pooled results ( p < 0.05).

Polygenic scores for behavioural traits None of the associations between PGSs for behavioural traits and SUD-related phenotypes surpassed multiple testing corrections, however, nominally significant associations ( p < 0.05) are detailed bellow.

So it should be kept in mind that each individual p value has a one-in-twenty chance of being nominally significant (p < 0.05) purely from random fluctuations.

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

In an earlier study of maternal smoking in Norwegian newborns ( Joubert et al., 2012 ) that identified 26 loci associated with maternal smoking during pregnancy, 19 passed quality control (QC) in our own analysis, and the association between methylation and ethnicity was found to be nominally significant (p<0.05)at 6 (31.6%) CpG loci.

Twenty one of the 24 multivariate GWAS loci reaching genome-wide significance had directionally consistent effects in the three studied datasets and 18 were nominally significant ( P < 0.05) in two or more datasets (Supplementary Fig. 1 ).

Of those, 38,776 (95%) showed the same direction of effect, 33,128 (81%) also had a nominally significant p value ( p < 0.05), and 25,544 (63%) had an FDR-adjusted p < 0.05 in the BLUEPRINT data (Fig. 1b , Supplementary Data 1 ).

Differential methylation analysis identified 6095 nominally significant differentially methylated CpG sites (DMCs; p < 0.05, log fold-change > 0.1), associated with 2935 unique genes.

Although 75 proteins showed nominally significant abundance differences ( p ≤ 0.05), all corresponding q‐values were 0.99, indicating no statistically robust differences in abundance between PEA and VC at 36 h.

Although the proteomic profiles of the 21 cyclophosphamide responders versus 14 non-responders overlapped by PCA ( Supplemental Data S3 ; Document S1 : Data S1 B, Figure S2 ; Tables S4 and S5 ), several immune-related proteins (e.g., IGHE, KIT, CD80, and IL-34) showed nominally significant differences ( p < 0.05), none of which remained significant after FDR correction.

We identified 74 nominally significant differentially methylated regions ( p < 0.05) in the mitochondrial genome, between anatomically separate cortical regions and the cerebellum in matched samples ( N = 3 matched donors).

In a second approach, we performed an MR using SNPs that were selected as IVs in EUR and that were nominally significant ( P < 0.05) in non-EUR.

48–50 We also identified lead SNPs (or the next most significant candidate SNPs) that were nominally significant at P < 0.05 in each independent sample. 48 , 50 Functional annotation Candidate SNPs were functionally annotated to characterize their biological significance ( Supplementary material ), identify SNPs with pathogenic potential [Combined Annotation Dependent Depletion (CADD) scores >12.37] 51 and highlight putative causal genes.

In accordance with the findings in mice, a nominally significant ( P <0.05) association between CDKAL1 rs4712523 and BMI was replicated in 2 Japanese general populations comprising 5,695 and 12,569 samples; the risk allele for type 2 diabetes was also associated with decreased BMI.

Some nominally significant effects were observed (i.e., covariate-adjusted differences between genotype groups at p < 0.05).

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

Each of the independent variables in the regression models was nominally significant, with p < 0.05.

Thirty additional associations (24 positive, six inverse) were nominally significant ( p < 0.05).

Similarly, urinary DAP metabolite concentrations, including DEP, DETP, DMDTP and DEDTP, showed nominally significant associations ( p < 0.05) with at least one of these two outcomes.

Moreover, in 3 of the 17 CpG sites linked to the DRD4 gene, associations with the Cue-P3 were nominally significant (p < 0.05) which can be seen in line with the findings of Albrecht et al .

The GWAS of patients with schizophrenia was performed using logistic regression with imputation probabilities adjusted for PCA covariates, chosen as nominally significant with p < 0.05 in the employed logistic regression.

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

In contrast to the other comparisons, the DD versus TD comparison only identified 59 nominally significant ( p < 0.05) DMRs (54% hypermethylated, 46% hypomethylated) from 1861 background regions that were assembled from the 25 122 420 CpGs covered in these groups ( Supplementary Material, Table S2C ).