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“showed a trend”

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In comparing 0N3R tau to the other five brain tau isoforms, most showed a trend toward less MAPK activation, with only 2N4R tau showing significantly less activation.
Tau in MAPK activation.
Front Neurol · 2013 · PMC3797993
116 In ZSF1 rats, an animal model of obesity, hypertension, and metabolic syndrome, chronic caffeine consumption showed a trend toward increasing plasma NE levels. 117 In human subjects, clonidine reduced alertness, impaired cognitive performance, and slowed saccadic eye movements; caffeine antagonized these impairments and opposed the blood pressure lowering effect of clonidine. 118 One interpretation of this study is that caffeine boosts noradrenergic signaling.
Furthermore, reaction time showed a trend for becoming slower with increasing MPEP dosage in both genotypes, with Fmr1 -KO mice responding overall significantly quicker to the correct aperture, reflective of quicker reaction times during earlier 5CSRTT learning phases (Figure 6D {2-way repeated measurements ANOVA [MPEP effect F (2, 54) = 2.26, p = 0.10], [Genotype effect p (1, 27) = 6.32, p = 0.01], [Interaction effect p (2, 54) = 0.17, p = 0.84]}).