In addition, variants at several loci including ST6GAL1, ACCS , and ITGAX showed a trend of increasing risk allele frequencies from the African, European to Asian samples of the HapMap project, suggesting that they may contribute cumulatively to geographical differences in the genetic susceptibility and thus the disease prevalence of IgA nephropathy [ 2 , 3 ].
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Clinical effect based on physician disease assessment was less striking but generally showed a trend for improvement compared with placebo.
Metabolically healthy obese black women, however, had a significantly increased cardiovascular risk, and overweight metabolically healthy black women showed a trend toward increased cardiovascular risk compared with normal weight metabolically healthy women ( Figure 2B ).
In contrast, DPP6-T showed a trend for increased expression in both disease states compared with nonfailing samples ( Figure 9 ).
64 – 66 One such study showed a trend toward improvement in insulin sensitivity after CPAP therapy using the hyperinsulinemic–euglycemic clamp; however, the degree of improvement did not reach statistical significance. 67 It is possible that the failure to obtain a statistically significant result was because mean nightly usage of CPAP in that study was only 3.6 hours.
The LEC to pPC synapses also showed a trend toward higher NMDA/AMPA ratios, although not significantly different compared to other FB synapses ( Fig. 6C , a ).
If the audio–visual stimuli were congruent this should elicit better performance, and while the data showed a trend for this, it was not strong enough to bring discrimination of consonant stimuli above chance levels.
Subgroup analysis showed a trend of increased risk of pure PDS (OR 2.08; 99.5% CI 0.93 to 4.66), pure EPS (OR 2.26; 99.5% CI 0.94 to 5.44), and overlap syndrome (OR 2.35; 99.5% CI 0.92 to 6.04) in women, but the differences were not significant after adjustment for multiple testing ( table 3 ).
Passive fear/anxiety showed a trend towards a reduction at test 1 and a non-significant decrease at test 2.
Although not differing significantly, the combination of COT plus UDCA showed a trend in reducing the risk of MOLT when compared with OBS (HR 2.05, 95% CI 0.50–8.93), monotherapy with UDCA (HR 2.63, 95% CI 0.72–10.75), COC plus UDCA (HR 2.55, 95% CI 0.44–15.03), MTX plus UDCA (HR 3.58, 95% CI 0.61–21.96), or BEF plus UDCA (HR 3.48, 95% CI 0.21–56.93).
Importantly, the left INS showed a trend Model I, which might be critically important for distinguishing depressive patients with and without anxiety disorder.
14 Chen et al 29 showed a trend of gradually reduced DMN functional connectivity from non-HE patients, to MHE patients using independent component analysis (ICA).
It should be noted that autoimmune disease itself was associated with an increased OR of malformation (OR, 6.95; 95% CI, 4.10–11.8); however, this association showed a trend opposite to that for exposure to corticosteroids and other immunosuppressants.
39 Our results suggest that anthocyanin supplementation reduced plasma MPO and showed a trend toward improvement in NAFLD fibrosis score.
Prosthetic breast reconstruction started late in China but showed a trend of rapid increase in recent years (Figure 2 ).
Many variables only showed a trend toward a difference, maybe due to the small sample size, which also prevented subgroup analyses.
Lymph node lymphocytes harvested after secondary infection showed a trend toward decreased calcium flux in nBmp2NLS tm compared to wild type mice, but the differences were not statistically significant ( Figure 7(d) ). 3.8.
Confirmation of fibrogenic cytokines with quantitative PCR showed that tgfb1 and pdgfa were significantly increased, and thbs1 , an activator of transforming growth factor-β, showed a trend toward increased expression ( Figure 4 B ).
Finally, PDAPP mice showed a trend towards higher fractions of firing cells at the tested current intensities compared to littermate controls (Figure 4E ).
Although the difference in survival outcomes between patients with GCs exhibiting loss or retention of ARID1A expression was not statistically significant, the latter group showed a trend toward better OS outcomes
Due to the small sample size of each group (10 patients), we decided to combine the two verum acupuncture groups (low and high dose groups) because (1) the total treatment time, needle stimulation time, and reported sensations were the same in both verum groups; (2) we found no clinical outcome differences between the two verum acupuncture groups and both verum acupuncture groups showed a trend towards improvement when compared to sham treatment, and (3) high and low dose acupuncture needle stimulations evoked similar activation patterns (Additional file 3 : Figure S3) ; ( 4) reported sensations as measured by MASS were similar in both real acupuncture treatment groups, and both showed significant differences from the sham acupuncture group; (5) acupuncture prescription for Knee OA varies across different studies; combining two protocols may better represent clinical acupuncture in practice; and (6) combining two groups gave us more power to test our hypothesis.
Although the number of surveillance colonoscopies showed a trend towards increasing tendency as the number of high-risk findings increased, there were no significant intergroup differences in terms of follow-up duration nor number of surveillance colonoscopies.
Both METH (25 μM) and Chlq (25 μM) showed a trend toward a reduction in NO production.
The results indicated that the water quality showed a trend of degradation from southwest to northeast, and the overall water quality level was exacerbated during the study period.
Comparison across urine BPA categories also showed a trend of higher PRL and PROG for women in the higher urine BPA categories, while only the association with PRL reached statistical significance.