“showed a trend”

Our present data also showed a trend for k 1 decreases, but statistical significance was not reached, most likely due to the small sample size of the study (Fig. 5 ).

Compared to the MSC-Ex treatment, however, UM-MSCs showed a trend towards a stronger reduction of the clinical symptom scores (Fig. 3B ).

Histopathologic and morphological analysis of heart post-MI showed reduced infarct size areas in animals treated with REMD2.59, whereas glucagon-injected animals showed a trend toward larger infarct size areas.

Total CI activity was significantly lower in HF compared with nonfailing samples ( Figure 3A ), whereas CIV activity in subsarcolemmal mitochondria showed a trend toward a decrease in HF ( Figure 3B ).

Mutated fibroblasts showed a trend toward disturbed cell proliferation, cell cycle arrest in G1 phase, and increased β-galactosidase activity, which is a consequence of an increased number of lysosomes (48) .

65 Interestingly, one study (GINDON study) showed a trend in favor of EGb 761 ® plus donepezil vs either agent alone, with regard to clinically meaningful cognitive functioning and global improvement. 55 Comparative data also demonstrated an improved safety profile with EGb 761 ® vs AChEIs and memantine. 65 3.6 Expert consensus/conclusion statements Herein, we summarize the Expert Panel's agreed consensus statements regarding the use of EGb 761 ® in the management of AD, VaD, BPSD, and MCI, along with other specific statements on clinically relevant issues (Table 2 ).

A post hoc analysis of data from the CHARISMA (Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance) trial in a subgroup of patients diagnosed with PAD showed a trend for a benefit of clopidogrel plus aspirin over aspirin alone in this population, with a reduction in MI rates. 19 , 34 At the time the REACH Registry was established, the novel oral antithrombotic agents prasugrel, ticagrelor, vorapaxar, or rivaroxaban were not available.

Intravenous administration also showed a trend toward improving composite score and sensorimotor function, although this was not statistically significant.

Conversely, PDIA6 overexpression showed a trend towards decreased apoptosis in A549 cells, although this did not reach statistical significance (Fig.

In the case of miR-122-5p, the results showed a trend to be higher in the HCV + group with respect to non-rejectors, but this difference was not statistically significant ( Figure 6C ).

ECs from triple-cell cultures also showed a trend toward reduced CDH5 expression in comparison with EC/SMC cultures, though this did not reach significance.

Our P-V loop analysis showed a trend of decreased cardiac output, stroke volume, and ± dp/dt in Akita, which were blunted in Akita/miR-133aTg heart.

RTLE patients showed a trend of smaller ipsilateral FA values only in the PHC ( 23 ).

Whereas quantitative reverse transcriptase PCR (qRT-PCR) analysis in livers of mice fed a CD showed a trend of decreased gene expression related to fatty acid oxidation and secretion in Arid1a LKO mice (Supplementary Fig. 3a-c), the mRNAs encoded by these genes involved in FAO ( Pparα , Cpt1a , Acox1 , Pgc1α , Hmgcs2 , etc.) and secretion ( Mttp ) were significantly reduced in the Arid1a LKO mice with HFD administration.

Viral suppression capacity was also significantly correlated with IFN-β and showed a trend for a positive correlation with IFN-α ( Fig. 6 b).

However, consistent with decreased pulmonary inflammation (Figure 4 A), total numbers of IL‐13 + CD4 + T cells and IL‐13 + ILC2s showed a trend towards reduction following α‐ICOS‐L treatment (Figure 6 C).

Survivorship analysis showed a trend toward a lower risk of revision and re-operation in patients with metaphyseal cones, despite their use in the most severe of bone defects.

2 , 3 Third, in none of our rodent experiments has NT3 treatment caused any detectable hypersensitivity, spasticity, or muscle weakness; rather, after bilateral CST injury in rats, intramuscular delivery of AAV‐preproNT3 reduced spasms, slightly improved grip strength, and showed a trend toward reducing mechanical hyperalgesia. 14 We used fMRI during electrical stimulation of the wrist to explore recovery of somatosensory responsiveness to adhesive patches attached to the wrist.

As when grown at 30°C, we noticed that OsEPF1oeS plants appeared smaller when grown at 40°C, so we assessed tiller development at 5 wk post germination and found that, although not significantly different ( P = 0.057), OsEPF1oeS showed a trend towards reduced tiller number (Fig.

The CD8 + T cells in the poly(I:C)-treated tumors showed a trend in increased expression of IFNγ ( Figure 3(d )), which was not statistically significant.

The whole structure of the oral microbiome of the VH group showed a trend to deviate from the other two groups The oral microbiome was profiled by sequencing of the bacterial 16S rRNA gene V3-V4 region.

DISCUSSION This study showed a trend of increasing prevalence of skin test positivity among school children and students with the increasing age (from primary school children to undergraduate students).

Regarding the concentrations of albumin, our results showed a trend of gradual increase with age being the highest on days 32 and 46 of fattening, thus helping to maintain the metabolic balance during the period of rapid growth.

Although less than 30% of the AZA patients completed the planned 12 cycles, the study showed a trend toward improvement in RFS in the patients receiving more AZA cycles. 101 Maintenance with CC-486, a novel oral AZA formulation that allows extended dosing and prolonged activity, has also been explored, although with limited data on frequency of prior therapy with HMAs. 98 Thirty patients in CR after alloSCT received CC-486 once daily for 7 or 14 days in a 28-day cycle for up to 12 cycles and among these, 9 had received AZA prior to transplant.

Further correlation analyses showed a trend toward negative correlation between serum pre-existing αAAV9 Abs and tissue AAV vg copy levels in the brain, liver, heart, kidney, and lung ( Figure 4 ), though it did not reach statistical significance (p > 0.05).