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showed a trend

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showed a trendp = 0.0491.0× alpha
Although patients showed a trend toward a higher proportion with fatigue ( p = 0.049) and with local swelling ( p = 0.063) after the second and third vaccination, respectively, correction for multiple testing revealed no significant differences between the groups (Figure S1 ).
showed a trendP = 0.04941.0× alpha
The T-VEC arm showed a trend towards better OS (23.3 vs. 18.9 months, unstratified hazard ratio (HR), 0.79; 95% confidence interval (CI), 0.62–1.00; P = 0.0494 [descriptive]) and a better DRR (19.0% vs. 1.4%, unadjusted odds ratio (OR), 16.6; 95% CI, 4.0–69.2; P < 0.0001) [ 73 ].
showed a trendP = 0.051.0× alpha
Although the mean median pitch remained within normal range with an overall non-significant change (−3.8, NS), analysis by gender showed a trend for statistical significance ( P = 0.05) on the impact on median pitch (i.e. the fundamental frequency): while it decreased among 80% of the female patients [from 203 ± 38 to 189 ± 31 Hz (normal range: 140–220 Hz), n = 19], it was almost unchanged in the male patients [from 135.2 ± 23 to 134.5 ± 26 Hz (normal range: 85–180 Hz), n = 29] ( Supplementary Fig. 1 ).
showed a trendp > 0.051.0× alpha
At the beginning of the trial, males showed a trend toward choosing the EO-treated arm, although no statistical differences were found (χ 2 = 2.46; p > 0.05), whereas females showed a preference for the EO-treated arm (χ 2 = 4.17; p = 0.04) ( Table 2 ), but no significant differences were observed at the end of the trial (χ 2 =3.11; p > 0.05).