However, subgroup analysis showed that even in patients with a history of trauma, the treatment effect in the experimental group still showed a trend of superiority (83.3% vs. 60.0%), and the main conclusion was supported by the large sample size in the subgroup without a history of trauma ( P < 0.001).
Analysis of adherence issues in relation to patient age showed a trend toward worse adherence to capecitabine therapy in the group of patients aged ≥80 years (hazard ratio =3.83; 95% confidence interval 2.48–5.91, P <0.001 versus 70–80 years group and versus <70 years group, chi-square test).
Patients in the interval group were older (P< 0.001) and showed a trend toward higher American Society of Anesthesiologists (ASA) physical status classification (P< 0.001).
In combined analysis, the addition of trastuzumab to paclitaxel resulted in a significant improvement in DFS (HR 0.52, P < 0.001) and reduction of death by 39% (OS, HR 0.61, P < 0.001) compared to paclitaxel alone.[ 13 ] The efficacy of concurrent versus sequential administration of trastuzumab showed a trend toward improvement in DFS in the concurrent arm; however, sequential was still better than placebo ( P < 0.001).
Paratyphi A, B showed a trend of increasingly reduced susceptibility against ciprofloxacin (χ 2 = 24.3 and 66.1 respectively, P < 0.001) throughout this study period (Table 3 ).
BSA sorption to lotrafilcon B showed a trend similar to HEL, with more BSA detected on the surface compared to the bulk region after the RINSE procedure, as seen in Figure 3C,D (p<0.001).
The decrease of VBP drug expenditures showed a trend of tertiary hospital ( β = −0.64, p < 0.001) > secondary hospital ( β = −0.57, p < 0.001) > primary healthcare centers ( β = −0.39, p < 0.001).
The CCL2 mRNA levels showed a trend to increase over time after stroke induction (day 1: 1.25±0.26 vs. 10.03±0.43, p=0.001; day 3: 4.85±0.07 vs. 10.33±0.98, p=0.001; day 5: 18.25±0.17 vs. 3.99±0.53, p=0.001; day 7: 35.79±0.33 vs. 2.66±0.79, p=0.001) ( Fig. 3C ).
Additionally, infections with typical bacteria were more common in patients with chronic lung disease ( p = 0.029), and typical bacterial infections showed a trend towards a higher prevalence with older age ( p = 0.001).
The MK and Sen's slope test showed a trend in the time series data with a significant decrease in humidity over the years by 13.3% RH in Kampala ( p = 0.001) and by 13.2% RH in Namutumba ( p = 0.035).
11 Further, pooled analysis of the TNT and IDEAL trials showed a trend for decreased CV event risk with lowering of triglycerides ( P < 0.001), although this was attenuated by adjustment for HDL-C and the ratio of apo B/apo A–I. 104 In T2DM patients, the FIELD and ACCORD Lipid studies showed that marked atherogenic dyslipidaemia (triglycerides ≥2.3 mmol/L or 204 mg/dL
Combined data from all the three studies showed a trend for a correlation between high OPN expression and high tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61–4.11, P <0.001) ( Figure 4 ) without any heterogeneity ( I 2 =0%, P =0.417).
The median overall survival in these patients receiving standard radiotherapy and concomitant temozolomide chemotherapy showed a trend towards better survival in group with methylated MGMT promoter (p < 0.001).
None of the predictors reached statistical significance, although sport before illness showed a trend-level negative association with BDI ( β = −0.26, t = −1.51, p = .001).
Doctors’ attitude showed a trend similar to the overall completeness, while nurses improved more consistently (p<0.001).
Central Corneal Sensitivity Suffered a Modest Reduction but Recovered to the Baseline Level during the 3-Month Treatment The significant differences observed from baseline to 3 months after treatment were as follows: (1) central corneal sensitivity suffered a reduction in 1 month after treatment ( F = 3.009, P =0.039) but returned to the baseline level at the final visit ( Figure 1(a) ), while changes in temporal corneal sensitivity were not statistically significant ( F = 2.462, P =0.074) but showed a trend similar to that of central corneal sensitivity ( Figure 1(b) ); (2) a significant reduction occurred in SE ( F = 106.499, P < 0.001), Km ( F = 39.960, P < 0.001), and E value ( F = 18.124, P < 0.001), while a remarkable improvement was found in UCVA ( F = 67.776, P < 0.001) and SRI ( F = 21.260, P
IDI, though not significant, showed a trend of improved classificatory ability compared with Model 1 (NRI [95% CI], 0.74 [0.31, 1.17], P < 0.001; IDI [95% CI], 0.05 [-0.01, 0.12], P = 0.126).
In all the three groups where samples were cultured in medium with different concentrations of TGF-β 1 , the total GAG/DNA value showed a trend of up-regulation by mechanical load, this difference was significant in the groups with 0 ng/ml ( P < 0.001) or 10 ng/ml TGF-β 1 ( P < 0.05).
Coughing, which had the highest baseline occurrence rate and severity, showed a trend of gradual attenuation with ongoing immunotherapy‐based combination treatment ( p < 0.001).
The second post-contrast imaging time showed a trend of higher ECV-values than the first time point, with an absolute deviation of 0.014 ± 0.016 for MOLLI ( p < 0.001), 0.008 ± 0.013 for SAPPHIRE ( p < 0.02), and 0.005 ± 0.020 for SASHA ( p = 0.24).
Those with the risk alleles of the other two polymorphisms showed a trend (at p <0.001, uncorrected) towards lower regional brain volumes.
The sEV-Phl treatment showed a trend of improvement in rotarod performance time starting from week 1 PMT, with significant differences observed at week 2 ( P < 0.001) and week 4 ( P < 0.005) compared to the corresponding MPTP group (Fig. 6 C).
were present in all samples, across time they showed a trend of higher abundance within amended samples with a significant difference at Time 2 ( p < 0.001) (Time 0—BBFs: av. 0.6%, ABBFs: 8.8%; Time 1—BBFs: av. 0.5%, ABBFs: 1.7%; Time 2—BBFs: av. 0.7%, ABBFs: 1.5%).
In the CSA 25° and 30° groups, the total intersection volume showed a trend of increasing and then decreasing with the increasing value of CPA ( r = 0.111, p < 0.001).
As shown in Figure 5 , pdBSI showed a trend toward a negative association with FMA in stroke patients ( r = –0.508, P < 0.001), mainly in the delta and theta frequency bands.