Furthermore, the percentage of cells assigned to each cell type in each sample was not significantly different between treatment groups ( Supplementary Table 3 ), except for excitatory cells subtype F showed a trend towards a higher percentage in CIE-treated mice (nominal p-value = 0.012) and OPCs that showed a trend towards a lower percentage in CIE-treated mice compared to controls (nominal p-value<0.05, Supplementary Fig. 2a , b ).
The level of PC education showed a trend where those with compulsory theoretical training were more likely to be in the upper quartile, whereas those without it were in the lower quartile ( p = 0.013); thus, the differences in curricula between universities with compulsory training (Messina and Palermo) and those without (Catania) could explain such differences.
23.8 months, P < 0.0001) and showed a trend to improved PFS ( P = 0.013) compared to patients not achieving NED status (Supplementary Fig.
Furthermore, the Chopart joint of the affected foot showed a trend towards reduced frontal plane ROM during the loading response ( p = 0.013) and a trend towards an increased ROM during the midstance phase ( p = 0.03).
In contrast, as our analysis showed a trend toward increasingly poorer prognoses as the time to spontaneous cessation increased (p=0.014), we cannot recommend long-term conservative treatment with the expectation of spontaneous cessation.
3E , r (15) = 0.646 , P = 0.005, P FDR = 0.031) mean patch-switching threshold, and showed a trend with the personal ( Fig. 3A , r (15) = 0.585, P = 0.014, P FDR = 0.05).
Long-term TTF users (>=12 months) showed a trend towards extended OS and PFS compared to shorter-term users, with a significantly lower adherence rate at 3 months in early discontinuation cases (p=0.014).
In the first line setting, although combination therapy generally showed a trend toward higher ORR across most mutation groups, statistical significance was observed only in the BRAF subgroup ( P = 0.014).
5.6 months, hazard ratio (HR): 0.653, 95% CI: 0.470–0.906, P=0.0102], furthermore, showed a trend towards improved OS (in PD-L1 positive subgroup: 32.8 vs. 19.5 months, HR: 0.615, 95% CI: 0.414–0.914, P=0.0148; in intent-to-treat (ITT) population: 33.1 vs. 23.5 months, HR: 0.691, 95% CI: 0.513–0.932, P=0.0145).
Having children showed a trend towards lower willingness (OR = 0.490, p = 0.015).
The proportion of this population among EpCAM-negative CTCs was significantly higher compared to EpCAM low and showed a trend-level increase compared to EpCAM high CTCs ( p = 0.0159 and p = 0.0637, relatively). 2.3.
EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P < .0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P < .0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P = .016).
Knockdown of AAEL009965, an uncharacterized protein, and FASN showed a trend toward reduced CHIKV infection (Figure 6B,D ; * p = 0.0163 and 0.0820, respectively), aligning with our RNA‐seq results.
Interestingly, some alpha diversity parameters showed a trend of difference, and ADONIS analysis based on unweighted unifrac distances suggested significant differences between the two groups (results not specified, p = 0.0167).
None of the three CAPs showed any significant difference in either of the two temporal properties when corrected for 3 comparisons using FDR, however, the DMLN CAP showed a trend towards reduced median duration in the HET group in comparison with WT ( p = 0.017, 2-sample T-test, uncorrected).
Patients showed a trend to improve at measurement D, compared to C (z = −2.38, p =.017).
9 Elderly patients with major depression have a poorer prognosis, are less responsive to treatment, and show greater functional decline compared with younger patients, highlighting the need for effective treatment; in this phase 3 double-blind study, esketamine nasal spray combined with a new oral antidepressant showed a trend toward improved efficacy in patients aged 65–74 years (p = 0.017) but not in those aged ≥75 years (p = 0.930), with continued improvement observed in the long-term open-label study. 2 Patients with treatment-resistant depression (TRD) have higher relapse rates and decreased daily functioning, and i
NP VDR mRNA Downregulation in LDD Patients Similar to blood VDR, the analysis of NP VDR expression also showed a trend toward lower levels in the LDD group compared to controls ( p = 0.018).
The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson’s r = -0.80, p = 0.018).
The PR group showed a trend of decreased frequency of CD4 + PD-1 + and CD8 + PD-1 + T cell subsets ( Figure 2(a) ) ( p =0.019, p =0.003).
In the multivariable analysis, controlling for both female and male age, female age showed a trend toward significance (OR = 1.12, 95% CI: 1.02 - 1.23, p = 0.02), while male age showed no significant effect (OR = 0.99, 95% CI: 0.92 - 1.06, p = 0.75).
Within the PD-1 hi populations, cells expressing either CXCR5 and/or CCR9 of pSS patients showed a trend of higher ICOS expression compared to HC but this was only significant in CCR9+ Tfh-like cells (28.6% and 55%, medians for HC and pSS, respectively, p = 0.02, Figure 2 B).
Especially towards the end of the experiment, biomass in the W treatment showed a trend of becoming higher than in the other two treatments, but a significant difference was only found between W and H treatments (KW test: chi 2 = 7.65, df = 2, p = .02, W‐H: p < .01) at the end of the second heatwave (day 21, Table S2 ).
The pooled RCT data showed a trend for higher miscarriage rate in the control group, which was statistically significant (RR 0.73, 95% CI 0.56–0.96; p = 0.02).
In the overall model, Education remained significant (aPR: 1.20, p = 0.03), whereas Labour Intensive Services, which was significant in the primary analysis, lost its significance (aPR: 1.04, p = 0.63) and Knowledge Intensive Services which showed a trend in the primary analysis became significant (aPR: 1.21, p = 0.02).