We analyzed the BE, ED and EA scorings of those five cases for which the entire pathology progression was available: hERG1 positive BE samples showed a trend to increase hERG1 expression during progression (Figure 1K and Supplementary Table S1 ).
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Accordingly, we could show that short intercellular distances in the epithelial compartment showed a trend towards a favourable prognosis, whereas in the stromal compartment long distances predicted an improved prognosis.
Kaplan-Meier survival analysis showed a trend toward even shorter overall survival in the patient group with Barx2-negative tumors, independent of advanced UICC stage and tumor relapse.
Transformations of ZnO–NPs had been previously reported in other species including some desert plants [ 43 ], where seed treatment with ZnO–NPs (8 nm) did not affect germination but the seedling roots showed a trend of reduced length and to transform the NPs into Zn-nitrate, Zn-phosphate, and Zn-citrate.
( 12 ) involving 68 men who underwent nerve-sparing radical prostatectomy, 30 men who received PVS to the frenulum daily for 6 weeks, using the Ferticare ® vibrator, showed a trend towards better erections.
Additionally, FGFRL1 (cg25932599; r = −0.27; p = 0.059) and PIPK1A (cg06936779; r = −0.26; p = 0.067) showed a trend for statistical correlation with BMI.
A study of 118 autopsies of subjects age 20 to 100, demonstrated increasing proportions of GM3 with age[ 40 ], and two neuropathological studies showed a trend of higher GM3 in basal ganglia of PD brains compared to controls[ 41 , 42 ].
Other markers such as vascular endothelial growth factor ( VEGF ), catechol O-methyl transferase ( COMT ), and tissue factor ( TF, a coagulation factor) were not significantly different from control although showed a trend toward a decreased expression.
In HC, this relation showed a trend towards the opposite direction (i.e. a higher DMN connectivity was related to a lower connectivity in the sensorimotor network), although this effect was not significant.
The extent of exposure, as indicated by area under the drug plasma concentration–time curve from time zero to the time of the last quantifiable data point (AUC last ) and C max , was generally similar between the matched treatment groups (Table 5 ), with the exception of the gMean ratio of AUC last for subjects with severe renal impairment, which showed a trend towards a higher value compared with matched healthy subjects.
The temporal variation of the depth of the siphon showed a trend similar to that of the distance between the end points of the lobes.
Exploratory analyses conducted to assess the impact of dilmapimod on CRP showed a trend of lower levels of CRP present at later time points (e.g. 72 h post dose) at all dilmapimod dose levels, relative to placebo [ 10 ].
In our analysis, there was a trend for group differences for the variables Loudness recruitment for 1 and 4 kHz (loudness scaling) ( p < 0.05), as well as for the variables Medium loudness level for 1 and 4 kHz (loudness scaling) ( p < 0.05), such that HAU showed a trend for higher values.
WT mice also showed a trend for increased GluN2B expression in the BLA but this was also not statistically significant [ F (1, 675) = 3.41, p = 0.065].
At the same time, the level of COL19A1 in HDFs was gradually increasing with the extension of time treated by BoNTA at the dosage of 5 U/10 6 cells ( Figure 6 ), and its level showed a trend of increasing when the dosage of BoNTA ranges from 2.5 U/10 6 cells to 7.5 U/10 6 cells ( Figure 6 ). 4.
Likewise, these people had significant higher non-fasting glucose levels and showed a trend toward higher levels of HbA1c and fasting glucose ( Table 1 ).
For the continental soccer confederations of South America (CONMEBOL) and North-Central America (CONCACAF), results showed a trend toward an expected relative age distribution, but results were not significant, South America, χ 2 (3, n = 115) = 4.03, p = 0.26, North and Central America, χ 2 (3, n = 92) = 0.96, p = 0.81.
Survival analysis showed a trend for better OS in patients treated for primary advanced ovarian cancer than in those treated for recurrence, but significantly better PFS.
All six groups, except for the low BMI group that did not develop diabetes, showed a trend of decreasing HOMA-β over time.
Although the data from mouse tumors showed a trend towards EMT inhibition by FILIP1L, they were not completely correlated with those from cultured cells.
Patients in the higher risk stratum of the CARRS score showed a trend towards lower survival, but this did not reach statistical significance (p = 0.411, Fig. 2 ).
While patients with higher expression of both BMI1 and CK2α showed a trend towards shorter progression free survival, the data did not reach statistical significance likely due to the limited sample size (Additional file 1 : Figure S2).
Comparison of NPDR patients with diabetic controls showed a trend toward a protective effect for haplogroup H, which was not greatly changed by adjusting for covariates ( Fig. 2 A, unadjusted odds ratio [OR] [95% confidence interval (CI)] 0.72 [0.50–1.04], P = 0.075; adjusted OR 0.75 [0.50–1.15], P = 0.20).
A high MMP-13 staining score showed a trend towards poorer survival [ 7 ] and a high MMP-13 expression level is associated with a high rate of liver metastasis [ 9 ].
Prediction In a series of HNSCC patients enrolled into a Phase III trial who received accelerated or standard fractionated RT, high EGFR expression (quantitatively assessed) showed a trend as independent determinant of OS [hazard ratio (95% CI for interaction): 0.75 (0.45-1.25)], PFS (hazard ratio (95% CI for interaction): 0.77 (0.45-1.31) and LRR (hazard ratio (95% CI for interaction): 0.88 (0.46-1.71)] in the accelerated arm, although statistical significance was not reached [ 25 ].