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“showed a trend”

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Subgrouping was performed in 66/89 patients and EFS showed a trend toward a poorer outcome for the 15 patients with SHH-tumors (2 with constitutional TP53 -mutations) versus patients with group 3 and 4 (#51) medulloblastoma (15-year EFS: 45.7%, 95% CI: 26.1%–80.2% vs 69.8%, 58.1%–83.9% CI: P = .065; Figure 4 ).
In isolated human islets, RO5166017 also showed a trend to increasing glucose-dependent insulin secretion, although this effect was not significant ( Figure 1 F). 3.2 TAAR1 agonist improved glucose tolerance During an oral glucose tolerance test (oGTT) in C57BL/6 mice, a single dose of RO5166017 (0.3 mg/kg, p.o.) significantly reduced glucose area under the curve (AUC 0–120 ) by 20% ( Figure 2 A) with no effect on fasting glucose.
In this regard, a subanalysis of the TRIBE study recently showed a trend for increased survival with FOLFOXIRI compared to FOLFIRI (irinotecan with fluorouracil and folinic acid) in BRAF-positive patients, this difference was not statistically significant possibly due to the low prevalence of BRAF-positive CRC. 54 Ongoing studies are evaluating BRAF inhibitors in combin