However, those with tandem GGDEF-EAL domains, most of which function as PDEs ( 25 , 34 ), showed a trend toward increased transcription.
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In the literature
In contrast, a recent retrospective registry‐based analysis of 397 patients undergoing carotid stenting showed a trend toward lower risk of 30‐day events among patients treated with high‐dose statins, suggesting a potential dose‐dependent benefit of statins in this population. 35 Furthermore, clinical trials of patients with stable coronary artery disease, such as TNT (Treating to New Targets), suggest an incremental clinical benefit of high‐dose statin therapy over moderate‐dose therapy. 36 Although it is unclear why we did not observe a similar dose response in the carotid stenosis population in this study, variations in study cohort and LDL levels may help explain this discrepancy.
Although the primary outcome of disease‐specific quality of life did not differ between groups, secondary analyses showed a trend toward reduction in HF symptoms and 30‐day readmissions in the group receiving meals. 20 The study by Lennie and colleagues 7 provides another important link between micronutrient deficiencies and outcomes in patients with HF.
All the metrics among different tissue types showed a trend of decline with time, with the exception of rFA, which displayed a paradoxical 10% increase in IC and TP in the first 60 minutes, followed by a subtle steady decrease to close to zero (i.e., nearly identical to the contralateral normal tissue [NT]).
Evo decreases body weight loss Compared with the control group, the MCMV mice showed a trend towards increased weight loss.
Haemodynamically stable PE + Syncope patients were more often treated with systemic thrombolysis and showed a trend to improved survial.
Maintenance BCG instillation showed a trend towards protective effect on recurrence free survival which failed to reach statistical significance ( Table 3 ).
At multivariate analysis adjusting for ARV regimen, VCY, CD4 cells count at nadir, GSS, only higher baseline VL (+1 log aHR 1.81, 95% CI 1.38 to 2.38, p < 0.001) resulted to be associated with higher risk of VF, while GSS showed a trend (Table 1).
On univariate analysis, histopathology (colorectal cancer) and radiation history ( Figure 3C ) were significant prognostic factors, while Karnofsky performance status showed a trend.
Immunisation with DacB and MetQ showed a trend in reducing the bacterial load.
Although no significant association with CKD progression could be found after correction for multiple testing, several candidate genes (including UMODL1 ) that had previously been related with CKD in the literature [ 96 , 98 , 100 ] showed a trend towards association with rapid CKD progression.
The RCT in India showed a trend towards increasing CS rate in the CTG group due to foetal distress compared to IA (47% vs 18%) [ 28 ].
In subgroup analysis, both in groups of greater (RD, 0.01, 95% CI −0.01 to 0.04, I 2 = 0%; P = .25) or less (RD, 0.06, 95% CI −0.02 to 0.12, I 2 = 29%; P = .20) than 50 μg showed a trend of higher risk to obtain hypotension with dexmedetomidine plus ropivacaine treated but without significant difference (Table 2 ). 4.
8 The few studies comparing HT and QT directly have found no differences in donor-site morbidity but showed a trend toward better functional results with QT. 9 , 10 , 11 Runer et al. 9 reported the results of 40 patients with at least 2 years' follow-up who underwent minimally invasive single-bundle QT autograft ACL reconstruction using the described technique.
Although we observed considerable variabilities in rejection ratio in some of sexual behavior assays using these mice, presumably due to viral injection surgery-associated stress, control groups in which saline was intraperitoneally injected before the assay still showed a trend of ESP22-induced increase of rejection ratio.
Additional LRTs (OR, 4.343; 95% CI, 0.963–19.590; P = 0.056) and liver failure (OR, 4.558; 95% CI, 0.958–21.693; P = 0.057) showed a trend toward severe adhesion but without statistical significance.
The GRM4 protein levels were also detected by Western blotting and showed a trend similar to that of the mRNA levels (Fig. 3c ).
Several other microorganisms, including Staphylococcus aureus , showed a trend towards lower prevalence among ivacaftor-treated than among comparator patients in both registries ( table 2 ).
Apparent clearance and t 1⁄2 showed a trend toward reduction in rate of elimination of montelukast.
inas; One-Way ANOVA, Dunnett’s multiple comparisons test) or DA levels (MKO: Mean ± SEM = 3.63 ± 0.15 ng/mg, n = 6 retinas; CKO: Mean ± SEM = 3.88 ± 0.07 ng/mg, n = 6 retinas; Control Mean ± SEM = 3.55 ± 0.22 ng/mg, n = 6 retinas; One-Way ANOVA, Dunnett’s multiple comparisons test), though CKO mice showed a trend toward increasing numbers of TH+ cells ( Figure 2C–D ).
Although the number of tumors was small, p53 knockout teratomas showed a trend towards lower levels of DSBs and accelerated tumor growth.
The completeness of the “PICU acceptance” portion of the checklist showed a trend toward improvement (Table 4 ) but was not statistically significant.
[ 12 – 14 , 25 – 27 ] Compared to intraaortic balloon pump, protected PCI with the Impella showed a trend toward lower MACCE after 90 days while there was no difference after 30 days.
Moreover, Kaplan–Meier analysis also showed a trend of different incidences of AF during the 5-year follow-up among the female patients who were treated with bisphosphonates, vitamin D, and neither treatment nor a significant difference in AF occurrence in 5-year follow-up (Fig. 2 A).
With respect to adult tissues, fetal cerebellum showed a trend toward down-regulation of p66 and a trend of up-regulation of p72, even though it didn't reach statistical significance (Figure 4A ).