None of the three CAPs showed any significant difference in either of the two temporal properties when corrected for 3 comparisons using FDR, however, the DMLN CAP showed a trend towards reduced median duration in the HET group in comparison with WT ( p = 0.017, 2-sample T-test, uncorrected).
9 Elderly patients with major depression have a poorer prognosis, are less responsive to treatment, and show greater functional decline compared with younger patients, highlighting the need for effective treatment; in this phase 3 double-blind study, esketamine nasal spray combined with a new oral antidepressant showed a trend toward improved efficacy in patients aged 65–74 years (p = 0.017) but not in those aged ≥75 years (p = 0.930), with continued improvement observed in the long-term open-label study. 2 Patients with treatment-resistant depression (TRD) have higher relapse rates and decreased daily functioning, and i
Pain scores showed a trend of decreasing scores from stage 1 to 4, although the significantly difference was only found between stage 1 and 4 ( P =0.017).
Patients showed a trend to improve at measurement D, compared to C (z = −2.38, p =.017).
NP VDR mRNA Downregulation in LDD Patients Similar to blood VDR, the analysis of NP VDR expression also showed a trend toward lower levels in the LDD group compared to controls ( p = 0.018).
The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson’s r = -0.80, p = 0.018).
During negative emotion regulation, the decreased left SMA activation in the NSSI group showed a trend-level correlation with higher DERS scores ( r = −0.44, P = 0.018), which did not survive the Bonferroni-corrected threshold of P < 0.017.
The PR group showed a trend of decreased frequency of CD4 + PD-1 + and CD8 + PD-1 + T cell subsets ( Figure 2(a) ) ( p =0.019, p =0.003).
The Welch’s t-tests, however, showed a trend with the board addition and a significant difference with board removal (C1 vs. + B: t = –2.4, df = 17.7, p = 0.02; C2 vs. –B: t = –5.7, df = 25.8, p = 0.00003).
Similar results were obtained when analyzing the NTs in the EC of Cohort II; the co-localization between p-tau217/p-tau231 and p-tau231/p-tau205 was significantly lower, and p-tau217/p-tau205 showed a trend to lower co-localization in AD high compared to PART ( p = 0.02, p = 0.04, and p = 0.06, respectively).
As for orientation angular velocity, the linear mixed-model ANOVA showed a trend between the experienced and naive groups (F 1, 59 = 5.5, p < 0.02) ( Figure 3 B).
In the overall model, Education remained significant (aPR: 1.20, p = 0.03), whereas Labour Intensive Services, which was significant in the primary analysis, lost its significance (aPR: 1.04, p = 0.63) and Knowledge Intensive Services which showed a trend in the primary analysis became significant (aPR: 1.21, p = 0.02).
Patients after PFA showed a trend of higher uptake than controls, reaching the boundaries of statistical significance for SUV peak (2.43 ± 0.42 vs 1.28 ± 0.15 P = 0.02) and SUV mean (2.30 ± 0.46 vs 1.12 ± 0.08 P = 0.014).
Moreover, patients with appropriate ICD therapy showed a trend toward lower right ventricular ejection fraction (RVEF) (development, P = 0.02; validation cohort, P = 0.22), with no significant differences in LV function and morphology (all P > 0.05).
Additionally, Delta stiffness showed a trend towards change (p = 0.02), while Delta CAP did not show such a trend (Supplementary Table 3 ).
In the multivariable analysis, controlling for both female and male age, female age showed a trend toward significance (OR = 1.12, 95% CI: 1.02 - 1.23, p = 0.02), while male age showed no significant effect (OR = 0.99, 95% CI: 0.92 - 1.06, p = 0.75).
Especially towards the end of the experiment, biomass in the W treatment showed a trend of becoming higher than in the other two treatments, but a significant difference was only found between W and H treatments (KW test: chi 2 = 7.65, df = 2, p = .02, W‐H: p < .01) at the end of the second heatwave (day 21, Table S2 ).
21 , 40 participants) showed a trend of risperidone being associated with less weight gain than haloperidol (1.74 kg [−0.62; 4.10], test for subgroup differences: Chi2 = 5.07, d f = 1, p = 0.02).
The pooled RCT data showed a trend for higher miscarriage rate in the control group, which was statistically significant (RR 0.73, 95% CI 0.56–0.96; p = 0.02).
Within the PD-1 hi populations, cells expressing either CXCR5 and/or CCR9 of pSS patients showed a trend of higher ICOS expression compared to HC but this was only significant in CCR9+ Tfh-like cells (28.6% and 55%, medians for HC and pSS, respectively, p = 0.02, Figure 2 B).
This showed a trend toward poorer outcomes among patients with a tumor-only DDR alteration [PSA50: adjusted OR 0.29 (0.10-0.78), P = 0.02; PSA-PFS: adjusted HR 1.65 (0.95-2.87), P = 0.07; OS: adjusted HR 1.51 (0.73-3.10), P = 0.26].
In GAC, CLDN18.2 expression showed a trend towards less invasive growth ( p = 0.02) and less common lymph node metastasis ( p = 0.07) and was more often observed within the EBV-associated subtype ( p = 0.01).
In addition, the levels of cell-bound IFN-γ showed a trend to be increased with the combination of sertraline and RT, which was inversely associated with tumor weight (R = −0.607 p = 0.021) (Fig. 7b ).
Bipolar disorder polygenic risk score, childhood adversity and symptom dimensions BD-PRS showed a trend-level association with the positive dimension (β = −0.49, 95% CI = [−0.875, −0.102], p = 0.021) but no association with the negative (β = 0.09, 95% CI = [−0.288, 0.474], p = 0.654), manic (β = −0.19, 95% CI = [−0.582, 0.208], p = 0.387) or depressive dimensions (β = −0.20, 95% CI = [−0.585, 0.178], p = 0.330).
Complications (yes vs no) also showed a trend towards significance (OR: 3.20, 95% CI: 1.20–8.53, P = 0.021).