“showed a trend”

Wnt1 directly suppresses osteoclastogenesis in a juxtacrine manner Because we did observe increased osteoclast number and eroded surface in Wnt1 Prrx1 –/– mice at 12 weeks, we next asked how does Wnt1 regulate osteoclast differentiation? There was no osteoclast phenotype in Wnt1 +/– mice in vivo, and although parathyroid hormone (PTH) treatment of total bone marrow from Wnt1 +/– mice showed a trend towards increased osteoclastogenesis, co‐culture experiments of control and Wnt1 +/– calvarial cells mixed with control and Wnt1 +/– hematopoietic cells did not indicate any significant osteoclast phenotype in Wnt1 +/– cells in vitro (Supporting Fig. 5A–D).

Down regulation of anti-apoptotic genes leads to apoptosis of the cells with damaged DNA which was induced by deoxycholic acid in vitro (Rawat et al., 2012) Furthermore, a pilot study in patients with barrette esophagus showed a trend which suggests that abrogation of IL-8 expression as well as significantly increased levels of apoptosis in the curcumin arm (Bhattacharyya et al., 2010).

59 Similarly in 123 angiographically documented patients with moderate to severe coronary artery disease, the Mount Abu Open Heart Trial of a multimodality intervention including Rajyoga meditation showed a trend towards regression of coronary lesions and a reduction in coronary events in those most adherent to the programme compared with those least adherent. 60 As noted earlier, there is a general difficulty in comparing studies due to the wide variation in study designs and populations.

While this BUBBLES study was not powered to demonstrate efficacy, collected clinical data showed a trend towards decreased morbidity and mortality.

As DElncRNA showed a trend of change similar to that of the DEmRNA and opposite to that of DEmiRNA, ceRNA network was constructed with 3 DEmiRNAs, 5 DElncRNAs, and 130 DEmRNAs.

In this post hoc analysis of patients with early RA and poor prognostic factors with an inadequate response to MTX across several outcome measures (except radiographs), abatacept showed a trend towards greater efficacy compared with adalimumab.

UNC fish showed a trend towards increased pattern distances that was, however, not significant when compared to NAV fish (p = 0.33; Fig. 4d ).

In addition, both training programs showed a trend forward to improve functional and strength variables when compared to the control group.

Various types of probiotics were used – Lactobacillus, Bifidobacterium, Streptococcus , and a combination of probiotics –and all showed a trend towards benefit [ 8 ].

The subjective attentional scores for the session and the block both showed a trend of increase as the practice sessions increased.

Cells at RT also showed a trend towards greater survival-rates when cultured (74.3 ± 2.9% and 67.7 ± 9.8%) than cells stored at 4 °C (54.8 ± 9.04% and 52.4 ± 8.1%) after 3 and 5-days storage ( p > 0.2 ).

Oligomycin state 4 respiration showed a trend of reduction in the HFD mice, and maximal FCCP-stimulated respiration was significantly reduced in in the HFD mice compared to control ( Figure 4C ).

PRO instruments showed a trend toward symptom improvement in the RUX arm that was not statistically significant.

The levels of IL-6, IL-10, interferon γ and TNFα, which are markers of inflammation, showed a trend towards increase from the beginning to the end of fasting but this increase was not significant.

Spatial Autocorrelation Analysis Moran’s I in the BTH region was positive for the six-year study period, indicating that the average PM 2.5 mass concentration in 13 cities showed spatial agglomeration, and as time went on, the spatial agglomeration level showed a trend of first rising and then declining ( Table 2 ).

Early CBF reductions showed a trend of high oxygen extraction fraction (suggesting classical ischemia), but this was inconsistent at later phases.

In addition, at baseline, both atorvastatin treatment groups (5 and 10 mg) showed a trend towards higher plasma levels of PCSK9 compared with the treatment-naïve study population (0 mg atorvastatin), although a direct comparison between these subjects may not be appropriate given the differences in the enrollment criteria with respect to LDL-C levels.

Soil salt in 0–20 cm and 40–60 cm layers showed a trend of lower volatility along with the growth of cotton plants.

Nintedanib, which also inhibits the receptors of VEGF, as well as platelet-derived growth factors (PDGFs) and fibroblast growth factors, showed a trend toward reducing declines in lung function, with fewer acute exacerbations and preserved quality of life [ 4 ].

Patients with BPH/LUTS-ED showed a trend to a higher MMN latency (242 ± 7 vs . 228 ± 7 ms for controls) (Fig. 4A ) and a significantly lower amplitude (1.6 ± 0.4 μV) than controls (5.5 ± 1 μV) (p < 0.01) (Fig. 4B ).

With the range from pH 2 to pH 11, the color of PSPAs solution gradually changed from dark red to blue, and the maximum absorption wavelength showed a trend shift toward the color blue.

Conclusions The ICR in the cervical spine showed a trend of moving progressively more superiorly and anteriorly and the disc space overlapping the distribution circle of ICR increased along the lower motion segments except the C5–6 segment.

Among the subgroups by eGFR trends, subjects with a decreased eGFR trend had a significantly higher risk of AF in those with the highest eGFR variability (Q4), whereas those with maintained eGFR or increased eGFR trends showed a trend for increased risk of AF in those with the highest eGFR variability (Q4).

The 3xT2A vector showed a trend toward higher frequency and absolute numbers of MHBs-specific CD8 + T cells when compared with Mix2A, albeit with no statistically significant difference.

Triple treatment showed a trend for survival benefit compared to single dose therapy (39 vs. 27 days median survival; n.s.).