Barely Significant
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“showed a trend”

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In the literature

20 Regarding disease progression, a study (C-OPERA) comparing a group of patients under CTZ+MTX combo versus a group of placebo + MTX patients showed a trend of greater modified Total Sharp Score change from baseline independently of positive titres of anti-CCP in both groups. 21 In another study comparing the efficacy of CTZ versus adalimumab, there were no baseline differences in anti-CCP positivity nor in the efficacy endpoints regarding the anti-CCP result. 22 This study has significant limitations inherent to its design, which implies a selection bias.
Only a few studies have compared mortality between MRSA pneumonia and non-MRSA pneumonia; one showed a trend toward higher in-hospital mortality among MRSA pneumonia patients [ 3 ], whereas another showed that MRSA infection did not affect intensive care unit (ICU) mortality or in-hospital mortality in patients with ventilator-associated pneumonia [ 4 ].
Breathlessness and exercise intolerance are the most common symptoms in COPD and progress relentlessly as the disease advances.[ 17 ] While all 60 (100%) subjects in our study presented with dyspnea, non-smokers with COPD showed a trend toward less severe shortness of breath compared to smokers with COPD.