Furthermore, an exploratory analysis from the ASCENT study specifically in the population with stable brain metastases showed a trend in PFS favoring sacituzumab over TPC (2.8 vs. 1.6 months) [ 50 ].
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Additionally, DF-HA showed a trend towards improved knee OA symptoms, including stiffness, physical function and pain.
Patients with SGST showed a trend towards poorer treatment response compared to patients from the non‐SGST group, but the finding did not achieve statistical significance ( P = .058, Fisher's exact test). 3.7 Response to treatment in SGST patients On a two‐step response scale, 8 patients showed a good response to treatment and 8 a poor response.
Next, we treated two ILC PDXs; while T125 showed a trend, T137 had a significant reduction in tumor growth (Fig 5F ).
Of the patients with severe NIV, 50% had blood–brain barrier (BBB) disruption and showed a trend of elevated interleukin levels in CSF.
The case was different with the G1888A and G1862C mutations, in which lower HBV DNA and serum AFP levels were observed in participants infected with the mutant strains than the WT strains, and the differences also showed a trend toward statistical significance.
Results Piglets from OEO supplemented sows were significantly heavier at one week of age and showed a trend for improved average daily weight gain from birth to weaning.
In female mice, ACC phosphorylation showed a trend toward increase in HFD-fed controls whereas it was unchanged in KPTIRKO mice ( Figure 5F ).
Nearly all these genes showed a trend for up-regulation in wild-type iris, with the exception of GCHFR , which is a negative regulator of GCH1 (which in turn codes for the rate-limiting enzyme of the pterin synthesis pathway).
The authors reported that as compared to non-users, metformin + DPP4-inhibitor combination group had a trend towards a reduced vertebral fracture risk (HR = 0.73, P = 0.013) and showed a trend towards lower non-vertebral fracture risk compared to metformin + sulfonylurea group.
RUNX2 and OSX transcription factors showed a trend towards upregulation at 21 days, with RUNX2 close to significance for fold change (Log 2 (FC) = 0.9).
Results: The incidence of the primary end point showed a trend to be lower in the probucol group compared with that in the control group despite reduced HDL-C without serious adverse events.
RT‐qPCR and ELISA were also performed to test the transcriptional level and secreted level, respectively, of the abovementioned cytokines (Figure 1C, D ), and the results showed a trend similar to that of the Western blot results.
However, at 180 d, the FS of each test group showed a trend of first increasing and then decreasing.
The chlorophyll content showed a trend consistent with phenotypic changes under salt stress.
While three out of four NK cell subsets showed a trend towards higher CD38 expression in SLE patients, only the CD56 + CD16 dim subset had significantly increased CD38 levels (2.2-fold increase, Figure 4 G).
Though satisfaction scores showed a trend in favour of the mixed delivery format, there were also indications that the group format provided a helpful normalising context in which participants drew encouragement from seeing peers engaged in the programme.
The correlation coefficient of the AC area showed a trend, but the result was not statistically significant (z = 1.874, p = 0.061).
Although statistically non-significant, for all thresholds, chronic pain participants then showed a trend of an increase in fractional occupancy over the first three sessions, with a drop in the last two sessions.
Compared to the conventional PTV, the DTI-PTV showed a trend towards volume reduction.
Furthermore, the prognostic value of the combination of ABCA2 and TFEB expression showed a trend for poor outcomes in PCa.
It can be found that the grain production efficiency in China’s main grain producing areas showed the features of uneven spatial development from 2001 to 2017, which generally showed a trend of decline from the central region to the eastern and western regions.
Thrombin activity showed a trend towards decrease in the non-ischemic hemisphere of the PAR1 KO as well ( Fig 3C ) with spatial variations ( Fig 3D ).
The cell density within both depots, and of PPARγ-positive adipocytes (the most abundant cell type in BAT), showed a trend toward decrease in Hoxa5 null compared to wild-type embryos at E18.5 ( Figures 5A,B,F,G,K ).
The positive rate of bFGF showed a trend similar to that of HIF-1α (Fig. 4A, F ).