Barely Significant
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“trending toward significance”

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In the literature

In a per-signature analysis, UPFL tumors were significantly enriched, as compared with UPPL tumors, for numerous subsets of T cells, including CD8 + , central memory, and effector memory, while trending toward significance for T follicular helper cells and γδ T cells (Bindea) ( Figure 4, C–G ), the latter of which are important for adaptive immunity at mucosal surfaces ( Figure 4G ).
While this pattern of mild-to-moderate improvement did appear in several other cognitive assessments [e.g., digit symbol substitution, word fluency, logical memory test two delayed recall, and Mini Mental State Exam (MMSE)] after t-PBM, these findings were only trending toward significance and only some patients were described in detail as having positive changes in cognition.
When using the mg/kg metric to evaluate bacterial community differences by AMU, similar results were found for both alpha (Chao: p < 0.01, Shannon: p = 0.01, Wald) and beta (Bray–Curtis: R 2 : 7.7%, p = 0.005, PERMANOVA, Unweighted UniFrac: R 2 : 5.4%, p = 0.03, PERMANOVA) diversity with the exception of weighted UniFrac (R 2 : 6.2%, p = 0.08, PERMANOVA), which had a lower p -value, trending toward significance, and explained a larger proportion of variance than with DDD. 3.8.3.
The association of fractures with thrombus formation varied according to the fracture classification, with wrist fractures (β=6.67, 95% CI: 0.92-48.10, p =0.06) and thighbone fractures (β=3.36, 95% CI: 1.01-11.13, p =0.05) both trending toward significance compared to thoracic vertebral fractures.
The risk of death was not associated with anticoagulant use in unadjusted or adjusted regression; however, death was strongly associated with large-vessel occlusion at the time of index event (HR 2.34, 95% CI: 1.11–4.93), with non-White race trending toward significance (HR 1.69, 95% CI: 0.85–3.37), and female sex (HR 0.39, 95% CI: 0.16–0.95) and prior hypertension (HR 0.31, 95% CI: 0.12–0.79) being protective of the outcome of death.
When limited to the microarray dataset, the PAM50-RORS and PAM50-RORP were trending toward significance ( supplemental Table S5 , available at Annals of Oncology online) and both were significant when the Nielsen series was included for a total of 280 luminal A patients ( supplemental Table S5 , available at Annals of Oncology online and PAM50-RORP in Figure 3 B).
The absence of a significant association between sVEGFR-3 and either PFS or OS in the IFN-α arm of the present study, although trending toward significance for OS, suggests that sVEGFR-3 may be more predictive of sunitinib efficacy than prognostic in RCC, but more research is necessary to address this question.