Excerpts

Severity analysis demonstrated a significant trend between increasing NVI severity and elevated risks of all-cause and DM-specific mortality.

In the unadjusted model (Model 1), obesity was significantly associated with higher odds of anxiety disorder (OR = 1.318, 95% CI: 1.091–1.593), while overweight status showed a marginally significant association (OR = 1.119, 95% CI: 0.995–1.258).

The final model (Model 5), which retained only significant variables, confirmed the persistent association between obesity (OR = 1.312, 95% CI: 1.084–1.589) and anxiety disorder, while underweight status approached significance (OR = 1.197, 95% CI: 0.993–1.441) (Table 2 ).

There was a decreasing trend in the frequency of discrepancies with increasing age.

After including social interaction and social support, the association between chronic loneliness and changes in Symbol search performance became significant (having been marginally significant in the main analyses).

Moreover, previous studies have shown inconsistencies regarding the strength of transient loneliness effects, ranging from significant but less strong than chronic loneliness [ 40 ], to somewhat significant depending on duration [ 42 ] and even no significance [ 41 ].

Globally, we observed a decreasing trend of PCV7 serotypes after its introduction in pediatric NIP which was offset by an increase of non-vaccine serotypes.

It was found that the association between ILI + A/H1N1 and acute appendicitis admission became marginally insignificant (cumulative ARR at 95th percentile: 0.966, 95% CI: 0.929–1.004).

In the continuous dose–response meta-analysis, which included 3 cross-sectional studies [ 51 , 54 , 57 ], a highly significant linear association between ST and the incidence or prevalence of myopia was found (P linearity = 0.000; P non-linearity = 0.4509) (Fig. 4 ).

high) was nearly significant in all models.

The burden of disease in low and middle SDI countries has been showing an increasing trend.

Except for Eastern Sub-Saharan Africa 0.15% (95% CI: 0.13 to 0.17), Southern Sub-Saharan Africa 0.4% (95% CI: 0 to 0.81), and Southeast Asia 0.28% (95% CI: 0.19 to 0.37), which has experienced a rise in the last 30 years, the remaining regions showed a decreasing trend.

However, when measured subjectively, there was a highly significant difference in both vigorous intensity PA and total PA level between the groups at the 12-month measurement session.

From 1990 to 2021, the disease burden of NTDm showed a decreasing trend globally and in the five SDI regions, but the disease burden remained high (Fig. 1 ).

A positive EAPC alongside a lower 95% CI bound above zero indicated an increasing trend, whereas a negative EAPC with an upper 95% CI bound below zero signified a declining trend [ 14 ].

1 , the number of occupational poisoning cases exhibited an increasing trend with age, and accidental poisoning cases were mostly distributed in subjects ≥ 65 years (27.90%, n = 4,133) and < 18 years (22.32%, n = 3,306), whereas the age distribution of intentional poisoning cases was similar to the overall.

These findings suggest an increasing trend in prediabetes prevalence over time, in line with the International Diabetes Federation’s projection that the number of people with impaired glucose tolerance (IGT) will reach 80.5 million by 2045 [ 59 ].

Among them, the protective effect against diabetes is extremely significant.

While taken together the two interventions (25% and 50% serving spoon size reductions) did not significantly reduce the amount of meat served, the daily decrease of ~ 12 lbs with a small effect size (SMD = 0.24) showed a trend in the expected direction.

While this trend approached significance with a medium-to-large effect size, the confidence interval (CI) was wide and included the null.

Higher teacher diet quality scores have been shown previously to be associated with healthier nutrition-related classroom practices [ 9 ], where teacher diet quality was a marginally significant predictor of classroom food practices, including use of food rewards [ 8 ].

Although it was not statistically significant, increasing distance was associated with a decreasing trend of uptake.

The uptake rates were found to be significantly varying across groups associated with different types of experiences ( p = 0.048). There was an increasing trend of uptake according to the rating of experience by the participants.

When VISIB was high, the risk of dengue fever increased, and as the lag period lengthened, the risk of onset showed a decreasing trend.

On the other hand, a WHO progress report published in 2024 showed the challenging reality of the control of STIs; the estimated number of new syphilis cases among adults aged 15–49 years increased by over one million in 2022, reaching eight million worldwide, and gonorrhoea case notification rates in selected high-income countries showed an increasing trend [ 5 ].