Excerpts

LPCs showed a trend towards reduced levels in samples from CCA, which reached statistical significance in those from PDAC patients.

In Korean women, the current mean age at menopause is lower than that in other countries such as the United Kingdom, Australia, or Japan but shows an increasing trend [ 17 ], which may possibly contribute to the increased breast cancer-related burden.

Subtype was significantly associated with the presence of distant metastasis at diagnosis and showed a trend towards significant association with lymphovascular invasion (LVI) at diagnosis, with a higher proportion of cases with LVI and distant metastasis for subtype A compared with B.

The presence of distant metastasis at diagnosis and recurrence after surgery are significantly more common for subtype A PNENs, and a trend towards significance was observed for LVI at diagnosis.

Even after adjusting for the cancer stage, the positivity of the D-marker panel and cancer progression remained associated with marginal significance, and the adjusted HR (95% CI) was 1.29 (0.92 to 1.80) (Model 2).

While tumour burden is likely to condition the patient’s survival and may explain the association between ctDNA detection and OS, ctDNA detection was less correlated with PFS in this study and was not significantly independent from other prognostic factors, despite a clear trend.

IL33Rα showed an association of borderline significance with cancer-related death, whereas highly significant associations were observed for the tumor characteristics and CRP levels.

The Eastern Cooperative Oncology Group (ECOG) performance status showed an association of borderline significance, whereas the Charlson comorbidity index and the American Society of Anesthesiologists (ASA) physical classification score showed no associations.

In this proof-of-concept study, a mild trend for reduced tumor volumes was observed when AAV vectors expressing anti-PD-1 scFv were combined with chemotherapy [ 189 ].

Moreover, an increasing trend was observed for administration of higher than prophylactic doses, with regards to the clinical oncology setting (line of systemic anticancer treatment).

Due to the limited number of samples, it was not possible to evaluate the significance of these values, which however show a positive trend. 3.

Despite a smaller cohort of TCP mice in our analysis, a clear trend in sex difference could also be observed.

The first interim analysis showed a trend towards OS benefit and an updated follow-up showed a maintained (albeit lesser) effect even four years after commencing study participation [ 50 ].

Downregulation of CerS5 was highly significant and accompanied by an increase in CerS1 and CerS3 expression in unstimulated Jurkat cells ( Figure 6 A).

Interestingly, both melanoma cell lines showed a trend to higher metabolic activity in ADA–GEL and HA-SH than mammary carcinoma cells during long-term cultivation (>7 days).

MCF-7 showed an overall trend for the highest apoptotic and necrotic rates.

A large, prospective, population based-study demonstrated a highly significant association between carriage of Porphyromonas gingivalis ( P. gingivalis ), and the risk of pancreatic cancer development [ 4 ].

In normoxia, MCF7-miR526b and MCF7-miR655 cell lines show an extremely significant upregulation of HIF-1α gene expression compared to MCF7 ( Figure 1 B) and SKBR3-miR526b cells showed an extremely significant increase in HIF-1α gene expression compared to SKBR3 ( Figure 1 C). 2.1.2.

On the other hand, there is a strong trend to discriminate malignant cells from the healthy ones by adjusting the threshold for CAR-T cell activation.

A recent report demonstrated that there was a numerical trend favoring ribociclib versus placebo for time to deterioration in global health-related quality of life (HRQoL).

milk), whereas milk + γBB showed a positive trend in the reduction of Cal 27 cell proliferation compared to milk ( Figure 1 k). 2.2.

Although recent achievements have shown that results generated on blood samples collected from minor studies of screening for CRC by direct colonoscopy may have a certain value [ 33 , 34 ], there may be significant discrepancies between results generated in blood-samples from symptomatic patients and subjects undergoing colonoscopy screening [ 35 ].

In this study, at the phylum level, we found positive trend of association between Bacteroidetes and the PNS cluster, and there was a negative trend or association between Proteobacteria, Firmicutes, and the PNS cluster prior to RT.

At the level of individual co-mutations, the presence of a DNMT3A mutation was significantly associated with complete clinical responses; in line with this finding, patients with co-mutations at the level of genes involved in DNA methylation pathway showed a trend toward achievement of a complete response [ 152 ].

Other highly significant changes mainly involve two proteins, COX2 for increase and VAT1 for decrease.