The according risk of developing oral cancer was 0.65% and 0.18%, whereby the risk difference of 0.47% was highly significant ( p < 0.0001; Log-Rank test).
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However, based on tumor grade, the decrease in HADHA transcript level is not significant (ns, p = 0.999) between normal and grade 1 tumors but it is highly significant between normal and grade 2 ( p < 0.0001) and 3 ( p < 0.001) tumors. 3.2.
Interestingly, seven out of the 110 genes present in the four high-scoring sub-networks were from the 263 genes mapping to bands q11 and q12 on chromosome 22 ( Figure S31 ), which is a highly significant enrichment ( p < 0.0001).
In addition, these remained highly significant after exclusion of outliers ( r = −0.525, p < 0.0001 and r = −0.507, p < 0.0001, respectively; Figure 2 b).
Highly significant up-regulation was observed in CIN III, CC, and TB categories ( p < 1 × 10 −4 ), consistent with activation of proliferative and inflammatory oncogenic miRNA programs.
In pilot clinical studies increased levels of Epi were detected in 20% of plasma samples collected from PC patients [ 27 ] and a highly significant positive correlation (0.91; p < 0,0001) was observed between increased blood Epi and the phosphorylation of S133CREB in prostate biopsies [ 58 ], which supports the relevance of preclinical model data to human prostate gland.
benign or normal groups were highly significant ( p < 0.0001).
obese was highly significant, **** p < 0.0001, whereas obesity-resistant vs . obese was also highly significant (**** p < 0.0001, TMCT), and no significant differences between lean and obesity-resistant mice were observed (ns, TMCT).
For discrimination of patients with metastasized NEN from presumably cured NEN patients, the combination of cfDNA concentration, hypomethylation, and cfDNA integrity revealed a highly significant AUC of 0.908 (95% CI, 0.83 to 0.99; p = 0.0001) with a positive predictive value (PPV) of 91.1% and negative predictive value (NPV) of 66.7% at the chosen classification cutoff of 0.5 ( Figure 4 B).
By correlating the immunohistochemical results with clinicopathological data, we demonstrated a highly significant correlation of NRF2 high and AKR1C3 high tumors with worse overall survival (OS) ( p < 0.0001 and p < 0.001, respectively) ( Table 1 and Table S1 ).
A highly significant association between the categorical PD-L1 TPS assessed by IHC and the continuous GEP-derived PD-L1 (CD274) was identified ( p = 0.00013).
In an analysis of subgroups according to grade, no difference in terms of occurrence of metastatic disease was observed for grade 1 and 2 tumours between the treatment periods, whereas a highly significant increase in the number of patients with metastases for grade 3 tumours was noted in the recent period ( p = 0.0002).
The Ctn reference ranges determined in this way for patients with nodular thyroid findings (90% confidence intervals) were <3.0 to 9.1 pg/mL for women and <3.0 to 14.1 pg/mL for men, i.e., very similar to the reference ranges specified by the manufacturer and with a highly significant sex difference ( p < 0.0002).
SLN status did not impact the prognostic strength of this risk score, since after stratifying by SLN status, the gene signature risk score remained highly significant ( p = 0.0002) ( Figure 3 ).
Significant or near-significant differences were found in the localization of the primary tumor (extrapelvic localization 86.4 vs. 61.6%, p = 0.0002) and the rate of applied MA (13.6 vs. 24.2%, p = 0.0686).
This meta-analysis failed to show any benefits of adjuvant bisphosphonates in premenopausal women, but highly significant improvements in bone recurrence (RR = 0.72; 95% CI 0.60–0.86, 2 p = 0.0002) and breast cancer mortality (RR = 0.82; 95% CI 0.73–0.93, 2 p = 0.002) were seen in the 11,767 postmenopausal women included in the meta-analysis.
Similarly, the Jaccard distance metric was highly significant (R2 0.47, p < 0.0003) for the HpN vs.
In contrast, the study connection was only marginally significant (OR 0.97; 95% CI 0.94–1.00; p = 0003) and did not link with the progression of proliferative alterations in males with prostate cancer (n = 22,773) compared to the control group (n = 23,050) [ 141 ].
The highly migratory cell lines (BxPC-3 and Panc-1) presented the highest oxygen consumption rate (OCR) ( Figure 1 E), and a highly significant correlation was observed between myoferlin abundance and basal OCR (r = 0.9997, P = 0.0003). 2.2.
The association was highly significant in women (OR = 1.68, 95% CI = 1.26–2.23, p = 3.54 × 10 −4 ), but not in men (OR = 1.14, 95% CI = 0.85–1.53, p = 0.39). 2.5.
As shown in Figure 4 B, those patients with score 2 showed a highly significant poorer survival than those patients with score 0 or 1 in the Kaplan–Meier analysis ( p = 0.0004 and p = 0.0040, respectively).
This enrichment was highly significant ( p = 0.0004) ( Table 1 ).
A comparison of the mEHT-treated and nontreated patients with the same stage brain tumors in the same research group in Italy [ 74 ] showed a highly significant ( p = 0.0006) response rate compared to the conventional control and also for GBM ( p = 0.026).
The difference in survival between the vehicle-treated control group and the NEO212-treated group was highly significant ( p = 0.0006).
At day 14, compared to untreated group the two-tailed p values of 46F2SIP and L19-IL2 groups were very significant ( p = 0.0041, p = 0.0047) and for 46F2SIP/L19-IL2 group were extremely significant ( p = 0.0006), indicating the strong efficacy of combined therapy.