Excerpts

Correlation analyses implied DC infiltration was somewhat linked to homing of T cells to MSI-H tumors but, overall, the association between APC and T cell frequencies displayed a negative trend regardless of MSI status.

CRC, a highly preventable disease, continues to remain the second most lethal cancer in the US with an increasing trend globally [ 1 ].

Patients with CD8 T RM -high, CD39+ CD8 T RM -high, and PD-L1+ CD8 T RM -high tumors showed a trend of better survival; however, the finding was not statistically significant ( Figure 4 ).

32 months, p = 0.10); nevertheless, there was a favorable trend in the conventional group for patients with bilobar neoplasia, portal hypertension, and elevated AFP [ 70 ].

No significant differences were found between the two PET radiopharmaceuticals on a per-patient-based analysis; conversely, a trend towards significance in favor of 18 F-FDOPA PET/CT was identified on a per-lesion-based analysis [ 28 ].

In contrast, Laurén’s classification, which is widely adopted, has not shown prognostic significance, even though a trend towards significance was seen.

* p -value < 0.05 was considered as a statistically significant and **** p -value < 0.0001 was considered as extremely significant.

Both LDN and LD-NDN showed a trend for a reduced expression of CD73 compared to NDN ( Figure 5 B).

An unplanned subgroup analysis showed a trend for enhanced EFS for patients aged 60 years or younger who received rituximab.

Moreover, patients receiving AC showed a trend towards a higher tumor burden as reflected by higher LDH serum levels upon ICI initiation.

0; significant improvement in PFS2, and a strong trend of improved OS) [ 13 , 14 ].

Likewise, a systematic review and meta-analysis reported an increased risk of ovarian cancer with higher BMI, and a marginally significant positive association with WC, but no association with hip circumference or WHR [ 42 ].

The incidence showed a downward near-significant trend for the younger age group (<18 years) (AAPC: −3.1% (95%CI −6.4 to +0.2), whereas estimation of a reliable AAPC was not possible for the young adults due to the low incidence in this group ( Figure 2 C).

A p -value of ≤0.10 was considered as borderline significant, and ≤0.05 as statistically significant. 3.

The intake of dietary calcium showed a trend similar to that reported in previous meta-analyses; however, these studies focused on BC incidence [ 107 , 108 ].

The results of our study confirm that the changes in the glycosylation level of fibrinogen were highly significant, with haptoglobin, serotransferrin, and, to some degree, hemopexin, also useful in the differentiation of LC patients from control subjects.

There was a similar but borderline significant trend for BAFF ( P trend = 0.08; Table S4 ).

There was a significant trend for immune biomarker levels according to the duration of smoking (≤5 years, >5 years), with the exception of MCP1 ( Table S5 ).

Preclinical data suggests that anti-PD-1 therapy and radiotherapy are best given concurrently, as there may be significant synergy between these two therapies [ 50 , 51 ].

In addition, tumor involvement in the optic apparatus and the GTV volume showed a trend towards contributing to the onset of this side effect.

However, this increase did represent a large relative increase (304.00%) in methylation, suggesting that it is likely to be significant from a biological standpoint.

Notably, patients with a preoperative L3SMI above the 75th percentile (>40.0375 cm 2 /m 2 ) of all patients showed a clear trend toward improved postoperative overall survival, when compared to the other patients (1435 (95% CI: 0–3222) days vs. 473 (95% CI: 218–728) days and 403 (95% CI: 109–697) days; log rank X 2 (2) = 5.303, p = 0.071; Figure 4 B).

Somewhat in contrast to the overall series, female sex correlated with better survival and volumetric findings were of borderline significance i.e., a larger tumor load predicted an adverse prognosis.

In addition, medium adherence to the Mediterranean diet protects from gastric cancer from low adherence between 16% for DS (aOR = 0.84; 95% CI = 0.62–1.13) and 57% for MDS (aOR = 0.43; CI 95% = 0.32–0.58), and although, in this case, the differences are not always statistically significant, a clear trend is observed ( Figure 1 ).

One study demonstrated certain organ involvement, thyroid for example, associated with favorable outcomes versus others that did not show a clear trend or were associated with worse prognosis [ 190 , 191 ]. 3.3.