Barely Significant

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highly significantp > 0.051.0× alphaqualifiedgold
Statistical analysis was done by Student's t-test, where the sample mean is used to estimate the population means and the corresponding p-value was obtained (p < 0.05 was considered significant, p < 0.01 was considered highly significant, and p > 0.05 was considered statistically insignificant).
a trend toward significancep = 0.051.0× alpha
A network metanalysis of five phase-III RCTs of triple combination therapy reported comparable improvement of ACQ scores in which both MD and HD ICS/LABA/LAMA FDCs and HD ICS/LABA FDC+TIO were equally (p > 0.05) effective in improving ACQ score, although a trend toward significance (p = 0.05) was detected for HD ICS/LABA/LAMA versus MD ICS/LABA/LAMA FDC [ 24 ].