Excerpts

Although all transcriptional changes presented were statistically significant, IL6 and pro-platelet basic protein had a p value trending close to significance (0.085 and 0.076, respectively) due to variability despite the observed fold increase in all treatment groups (Table S1 in Supplementary Material).

Furthermore, a retrospective analysis of patients receiving anti-TNF-α treatment for checkpoint enterocolitis showed a trend toward improved outcomes ( 47 ).

Moreover, for disease-specific factors, due to the concomitant occurrence of neurodegenerative disorders, use of higher doses of oral corticosteroids, and the propensity to malignancies and venous thromboembolism, BP mortality showed an increasing trend as well ( 19 , 29 – 36 ).

Although our results were not statistically significant, they showed a trend for the risk genotype.

This large-scale analysis demonstrated a highly significant 70% survival advantage among patients in medium or high level AIMP1 expression tertiles at 15 years postdiagnosis (Figure 6 E).

In order to further analyze nominally significant genes in the “TCR signaling pathway” and “cell cycle,” we performed unsupervised hierarchical clustering (Figure 5 D).

We find a clear trend for both the nonamer and decamer peptides with a set of HLA alleles where a bulk of the binding energy is provided by the “anchor” positions (Figures S11A,B in Supplementary Material).

18.8%; p = 0.549) did not differ significantly; however, it showed a clear trend of ineffectiveness of RTX in IgA-dominant cases.

Results showed an overall trend of increase in the frequency of CD3 − CD56 dim NK cell population at 14 days post vaccination compared to the 0 h baseline (Figure 4 ).

The prominent T FH phenotype present in the CP of MRL/lpr mice was supported by RNA-sequencing studies, which demonstrated highly significant differential expression of IL-21, ICOS, PD1, and CXCR5 (data not shown).

In contrast, 5/12 genes showed significant or near-significant sinusoid-like temporal (PP-independent) expression trends (Figure 7 A) of modest effect size (η 2 = 5–9%) (Table 4 ).

We observed that the neutralizing potential of the Abs in the serum was already highly significant on day 7 post i.v.; it increased further on day 14 and remained at the same high level until at least day 28, the last day tested (Figure 5 A).

This study is the first to demonstrate that older subjects with high NK activity post-vaccination tended to seroconvert better to the Brisbane strain and all influenza strains together compared to subjects with low NK activity; these effects were borderline significant.

Thus, considering that the number of daily new blisters only displayed a higher tendency in BP patients with mucosal involvement, the highly significant difference in the BPDAI scores associated to blisters and erosions lesions may be related to the presence of erosions rather than to new blisters.

In addition, there was a positive trend toward decreased level of TNF-α after MSC coculture, even though the result did not reach significance ( p = 0.064).

The beta diversity, however, accessed by using Jensen–Shannon divergence, showed a trend for reduction after changing to the short-vegetarian diet, and reached significance at the genus and species level (A vs.

However, we observed a positive trend between the level of fatigue and NKT-like cells (CD3 + CD16 +/− CD56 + ) (rho = 0.30), and a negative trend between the percentage of fatigue vs pain and NKG2C expression (rho = −0.33) (Figures S4B,C in Supplementary Material).

RT-qPCR analysis of mRNA showed a trend for increased CD163 expression after experimental stroke although this was not statistically significant (Figure 1 J).

The cells treated with inactivated BE, which contained inactivated JEV particles, showed a trend similar to that observed with infected BE treatment.

When we stratified the mice according to the S100a4 concentration in the BAL fluid (S100a4low versus S100a4high), the difference between the vehicle-treated mice and the niclosamide-treated, S100a4low mice became highly significant (Figure 7 C).

The highly significant correlation between the release of extracellular IPP and the expression of ABCA1 in many different cell types prompted us to further investigated the role of ABCA1/apoA-I in IPP efflux.

This analysis also revealed a highly significant reduction in the proportion of LSK cells without PU.1 (Figures 1 D,E).

Moreover, BRCA1 rs12516 CC genotype had a significantly higher BRCA1 protein expression, compared to CT/TT variant genotypes and RAD51 rs7180135 AA genotype had a borderline significant association to a higher expression of RAD51 protein, compared to RAD51 rs7180135 AG/GG variant genotypes.

Importantly, the effects of partial suppression were highly significant on both mRNA (Figure 7 A) and protein levels (Figure 7 B), indicating that the recombinant IL-10 was functional.

When we compared expression levels of these gene between CXCR5 − CD49d high CD4 + T cells and CXCR5 + CD4 + Tfh cells, CXCR5 − CD49d high CD4 + T cells showed a trend of higher expression of TBX21, EOMES, CXCR3, and PRDM1 and lower expression of IL-21, BCL-6 , and CXCR5 than Tfh cells, except BCL6 in the circulating Tfh cells ( 20 ) (Figure S3 in Supplementary Material).