Excerpts

Overall, our data indicate that ADCC responses may be significant for the control of HIV from an early stage during infection.

Overall, from the 88 samples, 21 target genes showed a highly significant correlation ( R > 0.8) with HLA-DRA and HLA-DRB1, HLA-DRA and B1 presenting the highest correlation ( R = 0.9).

The fact that we did not find differences between salivary and plasma IgA1 O -glycosylation, except for a slight trend of lower sialylation in saliva, is likely due to their inherently different biosynthetic pathways as compared to N -glycans, involving distinct glycosyltransferases ( 61 ).

The ribosomal protein transcripts aligned clearly, demonstrating an overall trend as opposed to a cluster-specific phenomenon.

For the LPS-O + used in the immunization schedule, but not for the LPS-O − , highly significant differences of more than 4.5 logs in the lung B. parapertussis colony-formation counts were obtained between the LPS-O + immunized animals and the negative control group or the LPS-O − -immunized animals ( p < 0.001; Figure 2B ).

MiR-21-5p mimic transfected DCs also showed a trend toward a reduction in CCR7 expression compared to the controls, although a statistical significance was not achieved (Figure 7C ).

MiR-21-5p mimic transfected DCs showed a clear trend of reduced CCR7 expression and a significantly decreased migratory ability toward the CCL21.

In addition, the MFI shifts depicted a significant MHC-II decrease before and after CpG activation with a decreasing trend for MHCI (Figures 1C,D ).

Additionally, CD160 + cells showed a trend to produce higher amounts of IFNγ compared to the control cells.

In the oropharyngeal compartment, rhinovirus infection was associated with a strong trend toward transient increases in the relative abundances of H. parainfluenzae, Neisseria subflava and a weak trend toward an increase in S. aureus ( 119 ).

parainfluenzae, Neisseria subflava and a weak trend toward an increase in S. aureus ( 119 ).

The RAND-36 questionnaire results showed a trend toward improved physical function in the intervention group, as compared to the placebo. bLF has been shown to prevent arthritis in experimental animal models ( 48 ).

The numbers of CD8 + IFN-γ + T cells also showed a trend of increase in liver and intestine in recipients of IL-17C −/− graft (Figure 2H ).

A slight trend toward increased branching and average process length and volume were noted in combination-treated mice.

Importantly, B-I09 also significantly reduced xenogeneic GVHD by the human T cells against murine liver (Figures 6A,C ) and modestly against mouse lungs that did not quite reach statistical significance (Figures 6A,D ).

Moreover, the hemocyanin content of all the diet groups showed a trend of reduction at 24 h compared with 12 h after A. hydrophila injection.

Furthermore, these cells expressed high level of the skin homing receptor CLA and there was a highly significant correlation between the number of these cells in the circulation and the size of the Leishmania -induced lesions in the skin.

The cancer cell lysate also induced expression of additional targets of the UPR in FL-DCs such as the ER chaperone BiP (Figure 1B ) and showed a trend in the induction of CHOP , a transcriptional regulator activated downstream of PERK (Figure 1B ).

Consistent with the above findings, neutrophil-mediated ADCC of SKBR3 cells using afucosylated trastuzumab resulted in a highly significant and prominent (up to ~80–90%) decrease in ADCC when compared to normally fucosylated trastuzumab ( Figure 4A ).

We found a higher percentage of H2D b -GP33-41 + CD8 + T cells in NFAT1 KO mice while NFAT1/2 DKO mice showed a trend of reduced frequency and significant decreased total numbers of H2D b -GP33-41 specific CTLs compared to WT controls ( Figures 2A,B , S2B – D ).

Recently, we have seen an increasing trend in the number of positive trials in which XRT is used to treat up to three metastatic sites.

Similarly, despite a positive trend, the correlation of plasma CXCL13 was not significant with plasma BAFF and sCD40L levels, two other indicators of B-cell activity (data not shown).

Sex differences in CD4+ cell counts were found to partially mediate sex differences in NK and T cell gene clusters #2, #3, and #4 to a highly significant degree.

In contrast, the expression of the proliferation marker Ki67 was increased on iNKT cell in all organs of C20:2 treated mice, while a clear trend of increase in Ki67 in iNKT cells was seen in spleen and MLN after treatment with C26:0 ( Figure 4H ).

Thus, we demonstrate that short-term treatment with C20:2 resulted in a highly significant anti-tumor effect in the Apc Min /+ tumor model, while short-term treatment with C26:0 did not have as potent anti-tumor effect as in long-term treatment.