Barely Significant

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In the LQ, MQ, and HQ groups, the content of acetic acid showed a decreasing trend, but there was no significant difference ( p > 0.05); the content of propionic acid was all significantly lower than that of the Q group ( p ≤ 0.001, p ≤ 0.01, p < 0.05); the content of butyric acid was all significantly higher than that of the M group ( p < 0.05, p ≤ 0.01, p ≤ 0.001). 5.7.
Notably, the blue module showed a specific high expression in gmsweet15 _24 h, the brown module showed a trend of upregulation after inoculation, but gmsweet15 mutant exhibited a more substantial upregulation, while the turquoise module showed a downward trend after inoculation, contrary to the brown module, and the downregulation in gmsweet15 mutant was more pronounced ( Figures 6A – C ; Supplementary Tables S11A–C ).
Our results revealed an increasing trend of small peptides (such as proline-Hydroxyproline, His-Ala, Ile-Ala, and Pro-Leu), the correlation analysis showed that the elevated serum levels of small peptides was negatively correlated with Escherichia-Shigella , Fusobacterium and Eubacterium_nodatum_group .