Barely Significant

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The worst predictions are for 5 and 6 , and it may be significant that conformations of these two less sterically-hindered substrates are predicted to be twisted but not perpendicular; then the solvent may have a greater influence on the conformation and hence on changes in conjugation energy during ionization.
Our study may be significant for better understanding the mechanisms of STZ action in chemotherapy and drug induced toxicity. streptozotocin HepG2 cells mitochondria oxidative stress GSH ROS pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY 1.