Excerpts

Interestingly, in the case of adding the Hep+ SP protein to a 500 μg/mL concentration, there was a negative trend on sperm viability after thawing.

A phase III clinical trial reported improved overall survival when L-MTP-PE was combined with systemic adjuvant osteosarcoma therapy for patients with nonmetastatic disease [ 116 ], and another study showed a trend towards improved survival in patients with metastatic disease with this same regime [ 201 ].

For cell wall hydrophobicity analysis, a strong trend was observed—cell wall hydrophobicity increased with DCF concentration ( Figure 3 b).

No significant differences were found in JSW loss compared to placebo at 24 months, while Kellgren and Lawrence grade 2 knees showed a trend towards less JSW loss.

As expected, the angiogenesis score was significantly associated with Nottingham pathological grade and American Joint Committee on Cancer (AJCC) cancer staging in METABRIC ( p = 0.009 and p < 0.001) but not in TCGA cohort, although tumors with metastasis (Stage IV, N3, M1) demonstrated a notable trend to be higher score ( Figure 2 A).

Intriguingly, the mRNA levels did not show a significant difference between the two cohorts, but protein levels showed a trend towards decline in the older cohort [ 100 ].

In a cylinder test to evaluate forelimb deficits, there was a trend toward significance showing that 30 μg of rat BMSC-derived extracellular vesicles increased percent usage of the impaired forelimb compared to PBS treatment [ 41 ].

We found several intriguing changes that may be significant when trying to evaluate the regenerative capability of these cells.

Then, the LLCH showed a lower but continuous and highly significant lipid accumulation over the cultivation period.

Discussion Infectious diseases of foreign origin have shown an increasing trend worldwide.

For all statistical tests, a P value less than 0.05 and 0.01 was taken to indicate a significant and highly significant difference, respectively.

A substantial and highly significant reduction in pancreas uptake was found in type 1 diabetic patients imaged with [ 11 C]-HTP [ 50 ], but conflicting studies reported that HTP also accumulates in other pancreatic endocrine or exocrine cells [ 72 ].

[ 22 ], a significantly higher number of ICM cells and a clear trend towards higher hatching ability was consistently observed in blastocysts derived from oocytes matured in vitro with LIF.

A balance in the differentiation between osteoblasts and adipocytes is extremely significant because adipocytes are a negative regulator of hematopoiesis and osteoblasts are promoters [ 14 , 72 , 73 ].

Most samples are graded 1 and the mean values do not show a clear trend from low to high collagenase concentrations.

In the case of two Pri-Endo markers, the expression level of PDGFα showed a decreasing trend during embryonic development; however, there were no significant differences between stages.

The other ICM and Pri-Endo marker genes showed an increasing trend; however, significant differences were not detected.

This highly significant difference may be attributable to three additive facts: a selection of more receptive cells by the freezing step of the tissue, a massive loss of infectivity of the Sendai virus aliquots used between experiments with rbF sample and control lines, and variable susceptibilities of the animals or tissues to the virus ( Table S3 ).

Red fruits from mycorrhizal plants showed a trend of higher BRIX values and increased levels of carotenoids in comparison to those from non-mycorrhizal plants.

[ 100 ] demonstrated a marginally significant association between high serum concentrations of total cholesterol and a reduced risk of kidney cancer.

The Faah expression showed a trend to gradually increase from day 7 and was significantly elevated on days 21 and 28 ( Figure 4 B).

1203 statistically highly significant ( q < 0.05; fold change > 1.5) DEGs (differentially expressed genes) were identified, among which 406 were upregulated and 707 downregulated ( Supplementary Table S1 ).

SIRT1 expression in Epi WAT was not changed by either maternal or paternal SIRT1 overexpression, although it showed a trend of recovering with the former approach.

To test whether the cell-lines are signified by a clear trend in expression, we compared MCF-7 and MDA-MB-231 to the reference of MCF-10A.

Multivariate analysis of variance revealed an extremely significant main effect of time ( F = 1496.4, p = 5.691 × 10 −30 < 0.001, Greenhouse–Geisser corrected).