Barely Significant

Excerpts

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The neutrophil/lymphocyte ratio (NLR) was significantly reduced in mild and moderate patients (mild: basal median 6.3 (range 3.8–10), 1 week median 3 (range 1.7–4) p < 0.023; moderate: basal median 6.9 (range 3.5–9.7), 1 week median 4.3 (range 2.5–6.6) p < 0.001), while it showed an increasing trend in patients who died (died: basal median 4.3 (range 2.8–12), 1 week median 8.8 (range 5.1–20) p = ns).
Another limitation is related to the sample size, which impedes the statistical significance reached in a comparative model: however, although the group × time interaction analyzed with a linear mixed factor analysis was not statistically significant, even though a clear trend is evident-for the weight and ALSFRS-R progression in this small pilot study, the findings on weight are extremely encouraging for conceiving a potential benefit for nutritional counseling and redefining a randomized, in-parallel, clinical trial.