Excerpts

This difference in proportions is highly significant ( P < 4E-5, Fisher’s exact test, two-sided).

Further examination of the tumor tissue sections after anti-PD-1 therapy revealed the co-localization of mast cells and FOXP3 + Treg cells, which was consistently observed and highly significant ( p = 0.000047) when compared to control-treated tumors (Fig. 4e ) and this may be associated with downmodulation of HLA class I on tumor cells (Fig. 3g, h, f ).

Migraine showed modestly significant genetic correlations (Bonferroni-corrected P < 4.8 × 10 − 5 ) with chronic pain duration and susceptibility ( r g > |0.5 | ).

A highly significant ( p value < 0.00005) likelihood ratio test compared to a standard logistic model supported that the mixed-effects model was better fit for our data.

When GWAS was performed in the 113 11q-deletion cases and 282 controls (78 undeleted 11q and 204 MNA neuroblastomas, Methods) of European-American ancestry, the 11q22.2 locus was still nominally significant (rs10895322, P = 5.50 × 10 −5 , OR = 2.811, logistic regression test, Supplementary Table 6 ), indicating a unique and independent role of the 11q22.2 locus in the 11q deletion cases.

We observed highly significant excess of CD missense URVs in EE/DEE (Fig. 1a , P = 0.0000643, OR = 1.09), whereas there was no significant excess of the other missense/inframe URVs ( P = 0.0861, OR = 1.01).

The pooled difference between Sr6 positive and null plants at 18 °C was highly significant ( p = 0.000074), whereas no significant difference was observed at 25 °C ( p = 0.75) (Fig. 2B ).

Finally, we verified that 13 out of the 16 life-shortening alleles are depleted in older study participants of the UK Biobank ( P =0.0021) and five of them have nominally significant association with participant age ( P =8.09 × 10 −5 ).

Across 16 novel and replicable loci, we found that multi-ancestry SLE-only GWAS already yielded genome-wide significant P values in 3 loci and borderline significant P values for the remaining 13 loci (highest P value = 8.19 × 10 −5 ).

We observed a highly significant increase in adjusted R 2 with the addition of ICA2 to the model ( F (1,507)=15.6, P =8.8 × 10 −5 ).

controls (148 alleles out of 24,758 = 0.6%) was highly significant [ p -value = 9.2 × 10 −5 , threshold = 0.05/ N , N = 1, by Fisher’s exact test (24,610:148 vs. 648:14)], indicating that this relatively common variant has in fact an effect on retinal health.

pistillata corals remained highly significant when comparing across treatments and sites ( p < 0.0001) (Fig. 2E ).

6c ) Stratified by 30-day survival, we found a highly significant correlation between LRT neutrophil elastase and galectin-3 in survivors only (Fig. 6d, r = 0.54, p < 0.0001), an effect that was also driven primarily by patients with ARDS, as well as patients classified to the hypoinflammatory subphenotype (Fig. 6e–f ).

This distribution of alternative and constitutive pG4 genes for each UTR context was found to be highly significant through permutation testing ( P value < 0.0001 for 5′ and 3′ UTRs).

The 19/24 published experiments with moderate, strong, or total loss of binding all showed highly significant ( P < 10 −4 ) negative contrast differences.

The linear correlations of L ↓ and K ↓ with T are highly significant ( p < 0.0001) for all the five reanalysis products.

Measuring the area under the curve (AUC) for mice proceeding to PID17 (PID3-PID17) ( n = 31) demonstrated a highly significant reduction in IFU in CTH522/CAF®01 vaccinated mice compared to control mice (Mann–Whitney U test, p < 0.0001) (Fig. 6f ).

Among the 12 loci associated with MG in the European meta GWAS, we identified nominally significant associations with same directional effects in the CTLA4 at 2q33 (rs231779, OR = 1.17, P = 1.0 × 10 −4 ), FAM76B at chromosome 11q21 (rs4409785, OR = 1.17, P = 0.030), and TNFRSF11A regions at 18q21 (rs7239261, OR = 1.14, P = 1.3 × 10 −3 ) in Japanese (Supplementary Table 2 ).

The associations of ap2-g and gexp-5 transcript abundance with gametocyte production remained highly significant after adjustment for gametocyte density at the time of measurement ( p < 0.0001).

While both regions act as mild enhancers in our assay, only the second variant (SNP 2) had a strong and highly significant difference in expression between the social and solitary alleles (Fig. 4c ; one-way ANOVA, F 4,20 = 65.0119, p < 0.0001).

Interestingly, fungal community structure was not significantly described by variance in material, while location had a relatively weak ( R = 0.129) though highly significant ( p < 0.0001) association, suggesting that variations in fungal communities that settle on materials (which have been shown to be driven largely by outdoor fungal communities 25 ) influence community structure upon experiencing wetting and high RH conditions.

In addition, after stem abundance was accounted for, maximum D was a highly significant predictor of species contributions to biomass (F=6,218, df=1,317, P <0.0001, R 2 =0.83, Fig. 4a ) and productivity (F=2,577, df=1,254, P <0.0001, R 2 =0.67, Fig. 4b ).

This correlation was highly significant, far higher than the maximum correlation observed in randomized comparisons (empirical P < 0.0001; N = 10,000 bootstraps, R max = 0.03, see Methods).

En masse , there were highly significant differences between the mutation spectra before and after chemotherapy ( P <0.0001, χ 2 test, Supplementary Fig. 10 ).

The model was highly significant ( P < 0.0001) and showed an improved R 2 m of 0.3180 (Fig. 4 , right; Supplementary Table 6a ), supporting an immunometabolic contribution to clinical severity within EBV-naïve/low participants.