Excerpts

All these differences were highly significant (pairwise two-tailed t-tests, P<0.0001).

While both regions act as mild enhancers in our assay, only the second variant (SNP 2) had a strong and highly significant difference in expression between the social and solitary alleles (Fig. 4c ; one-way ANOVA, F 4,20 = 65.0119, p < 0.0001).

For highly significant results where the exact value does not further impact scientific interpretation, p < 0.0001 is reported.

We found highly significant positive correlations ( r > 0.91, p < 0.0001, n = 324) between the fragment intensities of all samples and only very minor and non-significant deviations from a slope of one, with Δsl ranging from 0.008 (NADW/EMW) to up to 0.243 (Lake/AABW) (Fig. 2 ).

Interestingly, fungal community structure was not significantly described by variance in material, while location had a relatively weak ( R = 0.129) though highly significant ( p < 0.0001) association, suggesting that variations in fungal communities that settle on materials (which have been shown to be driven largely by outdoor fungal communities 25 ) influence community structure upon experiencing wetting and high RH conditions.

Statistical comparisons revealed a highly significant difference (20 min: median (IQR), 175 nm (98–259), n =7,964 vesicles from 100 synapses; 20 min+stim (161 nm (87–244), n =7,073 vesicles from 81 synapses), P <0.0001, Mann–Whitney test, Supplementary Fig. 5 ), consistent with the idea that stimulation brings about a small but robust condensation of the whole vesicle cluster towards the active zone.

A clear trend was observed: resource utilization width showed a negative correlation with MIP ( R 2 = 0.4901, p < 0.0001) and a positive correlation with MRO ( R 2 = 0.3465, p < 0.001) (Fig. 2c ).

3c ), highly significant effects in paired two-way t tests (weakest effect: p = 0.0001), indicating that our experimental conditions do give rise to the so-called stereo-movement suppression phenomenon.

In addition, after stem abundance was accounted for, maximum D was a highly significant predictor of species contributions to biomass (F=6,218, df=1,317, P <0.0001, R 2 =0.83, Fig. 4a ) and productivity (F=2,577, df=1,254, P <0.0001, R 2 =0.67, Fig. 4b ).

2 ) independent hairpin sequences had the same effect, each showing a highly significant reduction in cell viability upon treatment with 1 μM PD0325901 compared with DMSO treatment (two-sided t -test, P <0.0001, Fig. 1f ).

The Kaplan–Meier curve, however, does show a highly significant trend of loss-of-barrier function at higher concentration ( P < 0.0001 for both curve difference and trend significance, derived from log-rank tests) (Fig. 4i ).

Aligned rank transform three-way ANOVA analysis revealed significant effects of session and experimental day, and further demonstrated a highly significant interaction between group (TMP versus vehicle) and session (A, D, A*; P = 1.3 × 10 −4 ), indicating that cell ablation significantly but differentially affected learning in novel and familiar sessions (Fig. 5e ).

Disease had a highly significant ( p = 0.00017) impact on cell composition and steroid use was marginally significant ( p = 0.04680).

These loci were only nominally significant in the analysis including the svPPA patients ( LRP1B : P = 1.72 × 10 −4 ; OR = 4.66, COL22A1 : P = 0.03; OR = 5.32; TMEM135 : P = 1.68 × 10 −3 ; OR = 2.19, and TRPC4 P = 1.25 × 10 −4 ; OR = 2.91).

Reassuringly, the association with a clinical diagnosis of “vitamin D deficiency” (ICD-10 E55; N cases = 3150, N noncases = 344,619) was negative and nominally significant (i.e., higher DBP associated with a reduced risk of a clinical diagnosis of vitamin D deficiency; beta = −0.07, standard error = 0.02, P value < 1.9 × 10 −4 ).

These correlations were highly significant ( p < 1.96 × 10 − 4 ).

A pairwise combined microCT and gas exchange analysis of the four Arabidopsis lines revealed a highly significant positive correlation of g s and palisade porosity (Pearson correlation, r 2 = 0.471, P = 0.0002; Fig. 5l ), with the focl-1 mutant data grouping below those for the Col-0 control and on a par with the EPF2OE samples.

A Fisher's combined probability test revealed a significant trend for the five inactive female comparisons to agree with the results of the active female assays ( χ 2 10 =34.2, P =0.0002).

1b ) revealed highly significant correlations of PC1 and PC2 with hepatic zones (PC1: r = 0.47, p = 2.0 × 10 −4 ; PC2: r = 0.86, p < 2.2 × 10 −16 , Supplementary Figure 3) indicating zonation as a major driver of variation between samples.

The correlation between the number of BS and gene transcription levels was markedly significant (Supplementary Fig. 10c , p = 0.0002; Pearson correlation analysis).

The difference among body mass distributions of extinct, introduced, and remaining frugivore species was highly significant (ANOVA, F 37,2 = 10.343, p = 0.00027; Kruskal–Wallis Χ 2 = 16.477, p = 0.00026, see Supplementary Fig. 1 ).

However, when we performed mediation analysis, conditioning on the expression of TOP2B , the association between CX-5461 IC 50 and MYCN expression was lost ( P = 0.8), but TOP2B remained highly significant ( P = 2.7 × 10 −4 ), suggesting that the association between MYCN and CX-5461 IC 50 was mediated through MYCN ’s effect on TOP2B expression.

Depletion of SD1 showed a non-significant 1.07-fold fall ( p = 0.1815) in neutralization titers to Victoria, but a highly significant 1.9-fold fall in titers to XBB.1.5 ( p = 0.0003) (Fig. 5b ).

Variants in MT-CYB were nominally significant (p = 0.0003): MT-CYB (mitochondrial cytochrome b) is part of the mitochondrial respiratory chain, and essential for Complex III formation.

We also observed a nominally significant eQTL association within the same region of the ABO gene (Supplementary Fig. 2b ) at baseline (eQTL association signal for rs630510, p = 3.0 × 10 −4 in moderate LD r 2 = 0.27 with rs495828 pQTL SNP).