Excerpts

Similar findings also observed in forests fires, where fire total burned area decreased slightly yet average fire size even exhibited an increasing trend (Fig. 1 ).

2F did not reach the conventional statistical significance threshold, it displayed a trend toward significance.

Alternatively, using a more stringent statistical cutoff for protein, at p < 0.01, with a less stringent cutoff for mRNA, at p < 0.05 for the filtered dataset, a relatively higher percentage—33%—of the 446 statistically significant proteins were also significant by mRNA, and so significant protein-level associations were more likely to be significant by mRNA versus checking mRNA-level associations at the protein level, which may reflect in part some of the mRNAs involved not being translated into protein.

Of these 12,442 SV events, 1847 involved lower expression of the gene by both protein and mRNA (<−0.4 SD from the sample median for each analyte), representing a highly significant overlap between loss-of-function SV events and low gene expression events (3E-10, chi-squared test, Fig. 2a and Supplementary Data 3 ) and illustrating the importance of incorporating expression data loss of function predictions.

When comparing gene-level SV associations common between mRNA and protein, we utilized relaxed statistical criteria to lower false negatives, consistent with previous studies 46 , 70 , e.g., so as not to exclude significant mRNA associations where the association was at least nominally significant for protein.

We assessed the robustness parameter estimates, and whether there was likely to be significant differences between CT MAX evolution depending on nesting behaviour by conducting a bootstrap analysis with 1000 simulations as per Moen et al. 95 .

An increasing trend is observed for both maximum (red) and average (blue) values in scattering efficiency when decreasing confinement, indicating that the role of disorder is fully revealed in the strongly confined regime.

It could be seen that at both time points, the expression levels of COL2A1 in the blank group, NCCL-CG group, FCCL-DG group, and WCCL-DG group showed an increasing trend, and the WCCL-DG group was closest to the Sham group (Fig. 8a,b ).

Through Micro-CT analysis, newborn bone tissues in the hydrogel groups were arranged in an orderly manner, showing a clear trend of growth along the scaffold direction, while the appeared bone tissues of the blank group were disorderedly distributed and granular.

Intriguingly, 8-m-old male Lmna f/f ;AC mice exhibited a mild trend toward reduced average adipocyte size at room temperature (RT) (Fig. 4e ), accompanied by reduced mRNA levels of Ucp1 , Pgc1a , and Pparg in iWAT (Fig. 4g ).

In this work, experiments with 1 ppm of benzaldehyde, phenylacetaldehyde, and acetophenone show that NO concentrations ranging from 10 ppb to 1 ppm can enhance HOM yields by up to tenfold, with a decreasing trend at above 300 ppb NO.

Using grain LOX activity levels as phenotypic values, we consistently detected a highly significant GWAS signal for the Tu population grown in three different environments (Fig. 2b and Supplementary Fig. 3c, d ).

Instead, their binding showed a trend toward further increase in the more distal V H regions (Fig. 2b , and Supplementary Fig. 6b ).

We observe a clear trend among the models: models on average categorize 86% (±0.7%) of the statements as speciesist, but only label 37% (±0.8%) of the statements as morally wrong (see Fig. 1 ).

While there was a slight trend towards lower breathing rate over the course of task learning (Supplementary Fig. 2A ), trained mice showed a stable breathing rate of ~3 Hz that was not affected by odor pulse presentation (Supplementary Fig. 2B ).

For cholesterol metabolism, the high expression of APOE and LIPA genes in MP0 cells indicates that cholesterol metabolism in MP0 is under active regulation, with an overall trend toward enhanced cholesterol uptake, transport, and lysosome-mediated degradation, which helps maintain intracellular cholesterol homeostasis (Fig.

The VCNs showed a trend consistent with the fluorescence levels, with SRV2 RV transduced T and NK cells exhibiting slightly higher VCN values (Fig. 2e, j ).

3b ), SuSiE predominantly captured cell-type-specific patterns but missed numerous shared effects, whereas mvSuSiE excessively weighted on both cell-type-specific and shared-by-all patterns, resulting in an unexpected trend where the number of eGenes increased with the number of shared cell types.

Let \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{{\mathcal{H}}}}$$\end{document} H denote a set of marginally insignificant SNPs.

This is expected, as fine-mapping methods are designed to resolve strong signals within LD blocks, and typically work poorly for small genetic effects that are not even marginally significant.

An exploratory analysis suggested a numerical trend towards a higher MPR rate in patients with PD-L1 CPS ≥ 20 (57.1%, 4/7, 95%CI: 0.18–0.90) compared to those with CPS < 20 (22.2%, 2/9, 95%CI: 0.03–0.60).

In the first-line CheckMate 649 trial, EBVaGC patients showed a trend toward improved survival with nivolumab plus chemotherapy (HR 0.61, 95% CI 0.26–1.45) or nivolumab plus ipilimumab (HR 0.76, 95% CI 0.22–2.64) compared to chemotherapy alone, although these results were not statistically significant due to the small subgroup size 26 .

Similarly, protein expression levels of TFEB, TFE3, and MITF exhibited an increasing trend in both lung tissues of mice and various epithelial cells exposed to LPS (Fig. 8B ; Fig.

Using the ShinyGo engine 17 , we found highly significant enrichment of specific categories with minimal overlap between the functions of transcripts with different read lengths (Supplementary Fig. 8 ).

The calculated binding energies showed a clear trend, with Rh@Py-OMe (−25.5 eV) exhibiting the strongest binding, followed by Rh@Py-H (−21.3 eV), and then Rh@Py-OH (−13.1 eV) (Fig. 5 ).