Excerpts

In another patient (#62346) we found borderline non-significant low expression of MCOLN1 with 10 out of 11 reads expressing an intronic VUS (c.681-19A>C, Fig. 4f ).

While siRNA-mediated depletion of endogenous HSF1 in myofibers showed a trend toward increased TDP-43 aggregation, this was not statistically significant under the parameters and conditions tested (Fig. 7d ).

All GWS SNPs in this region yielded nominally significant opposite effect for the coded allele in TBLH-BMD as compared to TB-LM, despite the positive correlation between these traits.

Muscles of treated limbs exhibiting >46% of cMD1-positive fibres showed a trend towards a decrease in myofibre regeneration and of endomysial fibrosis ( Fig. 2b ).

The spectra exhibit a decreasing trend in the white-line intensities at 11,568 eV following this order: PtO 2 (2.20)>H 2 PtCl 6 (2.08)>0.2Pt/m-Al 2 O 3 -O 2 (1.66)≈0.2Pt/m-Al 2 O 3 -H 2 (1.65)>Pt foil (1.25) ( Supplementary Fig. 14 ) 37 38 .

Ectopic expression of Actβ produced an overall trend of decreasing the fraction of circulating hemocytes, although this effect remained statistically insignificant by t -test ( Fig. 3h ), and accumulation of hemocytes in ectopic areas seemed minimal ( Fig. 3c–f ).

Although this simulation has no trend in wind stress, it still has a positive trend in ice concentration and extent in this sector, and the signature of the heat trapping at depth associated with positive sea-ice concentration changes appears in the correlations.

Conversely, the negative timing reinforced group showed a trend toward decreased SPN excitation by the light (Fig. 3g–i ).

The majority of these proteins exhibited an increasing trend (Fig. 2d and Supplementary Fig. 2D ).

The Development and Interaction networks encompassed broad functional categories, spreading the networks’ genes among many different categories, so that enrichment results rarely survive multiple testing correction; nominally significant functional enrichment terms are therefore included for the annotation of the Development and Interaction networks (Fig. 2 , top panel ).

Correspondingly, AAV-SG1-shR-injected tau +/+ mice showed a trend towards higher levels of ERK phosphorylation 10 min after PTZ compared to AAV-ctr-shR-injected controls (Supplementary Fig. 8 ).

2k exhibits an increasing S content from the outside to the inside, a high P content in the outermost layer (from elemental P in the TPS layer) with a decreasing trend towards inside, and a N content that started from the middle layer (from elemental N in the PANS layer).

PROX1 ChIP-seq was validated by comparing results of ChIP-seq with two different PROX1 antibodies raised against separate epitopes (Millipore, 07-537 and Proteintech, 51043-1-AP), which showed a highly significant Pearson correlation ( R = 0.96).

On the other hand, it is also thought that psychological propensities to adopt and enforce norms have been subject to significant evolutionary pressures, suggesting there may be significant limitations on the range of possible norms 16 .

FC showed a trend of increase of sweep numbers in SNI group compared to naïve group (Fig. 4c ).

rmTBI led to a statistical trend in increased Aβ deposition and treatment with cis mAb also prevented the increase (Supplementary Fig. 9d, e ).

8b, c , λ m fluctuates in a non-monotonic way but still exhibits an increasing trend on the whole; when v ex is very small, λ m < λ mc , indicating that the responses are periodic (or quasiperiodic).

This is quite significant given that typical PFOS adsorbent materials reported up to date would involve only one or two of these driving forces 51 , and offers clues on why SCU-8 exhibits such advantages in term of sorption kinetics and efficiency over other reported sorbent materials.

Comparison with the gene expression data revealed a highly significant enrichment of PU.1 binding in genes that required PU.1 or PU.1 and SpiB for their expression (Fig. 5c and Supplementary Data).

A P value of <0.05 was considered statistically significant and a P value of <0.01 was highly significant.

Moreover, when the size of phage-displayed monocycles was gradually increased by insertion of additional residues between the serine and cysteine residues, highly significant peptide modification was observed for all tested constructs (Supplementary Fig. 1 ).

Major hurricane frequency is consistently related to relative SST 5 (difference between MDR SST and tropical mean SST), as they are correlated while neither index has an obvious trend (Fig. 2b ).

We found that the CDR3B length distribution for proinsulin-specific 39 and autoreactive clones 31 – 38 shows a clear trend to being shorter than expected (Fig. 8e, f ).

Associated with this GDF8 decrease, an important trend to an increase of circulating FSTN was observed (SMA 135.6% ± 71.3 and DMD 189.4% ± 35.2 compared with controls, respectively) (Fig. 1d ).

We found an almost significant deficit of genes responding to sexual selection on the older part of the X chromosome (XL) and that XR contains a deficit of sex-biased genes.