Excerpts

The results of the crossover analyses indicated that a maternal supplement of a combination of folic acid and multivitamin (AOR = 0.67, 95% CI = 0.50~0.90), as well as maternal supplement of a combination of folic acid and iron (AOR = 0.70, 95% CI = 0.52~0.96) significantly decreased the risk of obesity in preschoolers born SGA; while only maternal folic acid supplementation during pregnancy decreased the risk of obesity with significance (AOR = 0.73, 95% CI = 0.55~0.97) in the crossover analysis on a combination of folic acid and multivitamin, and marginal significance (AOR = 0.77, 95% CI = 0.57~1.04) in the crossover analysis on a combination of folic acid and iron, respectively.

The effects were only mildly significant.

Predicted biotin biosynthesis was enriched in KO relative to WT mice and was nominally significant, though the q-value did not fall below the alpha of 0.05 following Benjamini-Hochberg correction ( q = 0.0872).

Regarding obesity-related disorders, the presence of type 2 diabetes before surgery was associated with a significant decrease in %TWL in both the univariate and multivariate analyses ( Table 2 ), as well as with a decreasing trend in %EWL ( Table 3 ). 3.3.

Habitual regular cola consumers had a borderline significant age-adjusted association with PanCa mortality (HR: 1.43, 95% CI: 0.99, 2.07) that was attenuated in the multivariable-adjusted model (HR: 1.38, 95% CI: 0.91, 2.07).

Moreover, the BMI showed an increasing trend in all age groups, as shown in Figure 2 .

Although SSB consumption still remains high in many high-income countries, a decreasing trend considering specific age ranges can be noticed, while studies show increased levels of SSB consumption in low- and middle-income countries [ 35 ].

Furthermore, the iAUC for GLP-1 in the Dose A group exhibited an increasing trend, and the Dose B group had a significantly higher iAUC value than the Placebo group.

Bonferroni correction was applied to account for the multiple testing (a total of 28 FAs), where p -value < 0.002 (0.05/28) was regarded as statistically significant and p -value < 0.05 was regarded as nominally significant [ 29 ].

There was a statistical trend regarding hepatobiliary malignancies occurring more commonly in patients with a severe vitamin D deficiency than in patients without a severe deficiency (11% vs. 5%, p = 0.07; Table 1 ).

After adjustments for clinical and laboratory parameters, it was revealed that when taking the Q1 quartile of TyG index as a reference, an increasing trend of VDD prevalence was presented in the other three groups divided by TyG index quartiles, where the OR (95% CI) was 1.708 (1.132–2.576) for Q2, 2.041 (1.315–3.169) for Q3, and 2.543 (1.520–4.253) for Q4 (all p < 0.05).

There was also a positive trend noted for SFN in ADHD (Attention-Deficit Hyperactivity Disorder) symptom improvement measured with the ABC-H survey (Aberrant Behavior Checklist Hyperactivity/Noncompliance subscale) [ 28 , 29 , 30 , 31 ].

In recent years, it has been reported that disturbances in the dark–light cycle, which generate a condition similar to shift work or chronic jet lag, showed a trend in alterations in bone structure and bone loss [ 89 ].

In both Figure 2 A,B, there was a steady shift of the mean values from the left to the right, which implies an increasing trend with time.

With the inclusion of age and gender as controls in Model 2, the coefficients of social capital components among the rural children were no longer significant, the significant coefficients of neighborhood bonding trust and neighborhood bridging trust on BAZ among the total child respondents were retained, and neighborhood bonding trust exerted a marginally significant effect on the BAZ scores of the rural children.

observed a borderline non-significant linear relationship between increasing tree nut doses and TG reductions; no dose-response relationship was observed for HDL-C [ 16 ].

Vitamin B12 and folate also showed a trend of lower intakes in ASD-C, and two studies reported significantly lower levels in contrast to TD-C [ 27 , 55 ].

The time series analysis of data, i.e., the ability of each trimester to predict the number of new diagnoses in the following trimester, revealed a clear tendency to reduce the degree of autocorrelation between trimesters in the period immediately before the first lockdown (Ljung–Box test borderline significant).

Simultaneously, fecal moisture content showed an increasing trend.

Comparison of the ≥60 group with the 41–50 group demonstrated that the older subjects had highly significant values for BMI and hs troponin I.

Through stratified analysis in Figure 2 , we found that in most subgroups, CVD and all-cause mortality still showed a decreasing trend with increasing AC or AC/WC.

While the sample size is modest, the differences in gastric transit are highly significant and biologically relevant.

Compared to the HUA group, 15 metabolites were significantly increased and 9 metabolites were significantly decreased in the anserine intervention groups, with fructose, xylose, threonine D-glucuronide and methionine showing an increasing trend, and glycine and pipecolic acid showing a decreasing trend ( Figure 8 B).

The global prevalence of NAFLD was estimated at 32.4% (95% CI 29.9–34.9), with male predominance and an increasing trend over time [ 9 ].

In the heat cluster map ( Figure 5 A), the gene expression of the ALI group and LP-cs-presupplemented group showed significant differences as compared with the control, and a very different clustering was observed in the LP-cs-Gel-presupplemented group, which indicated that there might be significant differences between LP-cs-Gel and LP-cs in the effect and molecular regulation mechanism.