Barely Significant

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ce Four studies reported on AMR.[ 36 , 46 , 48 , 54 ] In a study by Chan and co-workers, the rate of methicillin resistant Staphylococcus aureus (MRSA) decreased from 65–70% before the implementation of the antimicrobial approval system in 2003 to less than 60% in 2009.[ 46 ] Buising and co-workers showed a trend after the introduction of an antimicrobial approval system towards increased susceptibility of S . aureus to methicillin and increasing susceptibility of P seudomonas spp. isolates to both carbapenems and aminoglycosides.[ 48 ] Use and implementation Fifteen studies assessed aspects of the use and implementation of CDS, such as user satisfaction,[ 2 , 33 , 52 , 67 – 69 ] user uptake,[ 37 , 48 , 59 , 68 ] and acceptance of CDS recommendations.[ 38 , 46 , 50 , 51 , 59 , 70 , 71 , 72 ] Six studies showed improvement of user uptake and satisfaction.
Group-specific examination revealed that the beneficial intervention effect on leg lean mass was due to an adverse change within the control group, suggesting that their high sedentary time throughout the year and an increasing trend in sedentary leisure time at the end of the study were hazardous, but even a small decrease in the intervention group’s leisure sedentary time was enough to prevent a decrease in leg lean mass.
SSPE (isolated or multiple) were 8.8% (CI 7.1–10.5%) of all diagnosed PE with prevalence ranging from 2.0 to 15.9% of diagnosed PE, with only three marginally significant differences on pairwise comparisons.