Excerpts

Discussion In one of the first investigations of this hypothesis using a GWAS approach, we identified a borderline significant association for rs100009124 and number of children when corrected for multiple comparisons in our analysis.

Both vitamin D and folate levels showed only nominally significant effects.

Particularly, males showed a trend of improvement of their local clustering whereas females exhibited a significant decrease of local clustering, which was further validated in the FA-based structural network ( S1 and S2 Tables).

Among the top overrepresented terms, based on highly significant FDRs and number of differentially transcribed genes (i.e. > 30 microarray features) associated with each term, were those associated with muscle cell growth and development (e.g. sarcomere, myofibril) and cardiac muscle/heart development.

3A ): (1) The amount of Gammaproteobacteria in controls maintained the same predominance for 9 days before NEC onset, yet it is significantly higher in controls than in NEC samples at 7–9 and 4–6 days prior to NEC onset (p = 0.01 and 0.008, respectively), and not significantly different just before disease onset as a result of Gammaproteobacteria from NEC cases showing an increasing trend while approaching disease.

We found an increasing trend in the weighted and unadjusted prevalence of metabolic syndrome and high-risk FRS in males and females according to deciles of albuminuria ( Fig. 3 ).

Although the OLS regression was highly significant, we believe that model quality can be further improved, at least for δ 18 O and δ 2 H.

Contrary to expectations, we did not find either δ 18 O or δ 2 H correlated with altitude, probably because we considered a wide area characterised by fairly significant climatic variability which may have masked the altitude effect.

There was no difference in the BMI between men in our study populations and two reference populations even if a highly significant difference in VAT was found.

Our analysis further pointed out changes in aldosterone signaling, which are likely to be significant in the biliary tract because bile production depends on osmotic effects triggered by secretion of both bile acid and sodium [ 47 ].

The error rate in the standard trials was larger in the fatigue state with an increasing trend, but without significant difference.

Our previous results using a standard QTL method based on linkage mapping provided us with numerous QTL; however, the GWAS detected a lower number of markers with a highly significant association.

Interestingly, although the retention ratio exhibited a decreasing trend with time, there was no significant difference among the different injection time points ( Fig. 6B ).

multilocularis in definitive hosts [ 13 ], and our data suggest that such a dilution effect ( sensu [ 13 ]) may be significant in summer but absent in winter, when only competent intermediate host species are consumed ( Fig. 2B ).

This last hypothesis is consistent with our fecundity model selection results, which showed a weak trend for average fecundity to decline during winters with thin snowpack (high PDO values) while breeding effort did not.

This was done by profiling the expression of the selected 11 genes that showed a trend toward significant transcriptional differences before the correction for multiple testing.

The Fst values between the Brazil and Belize populations were greater than 0.20 and were highly significant for all comparisons ( Table 4 ), indicating particularly high differentiation between these stocks.

The kinetics of the putatively annotated DON-hexitol did not show a clear trend between wheat lines harboring Fhb1 and without.

Stormwater runoff pollution is a very serious problem, and the temporal and spatial variations in this pollution process can be quite significant in rapidly industrialized cities, because fast urbanization and industrialization are usually characterized by an increase in the number of factories and population density, as well as the drastic changes in land-use, moving from farmland and green land to impervious surfaces [ 12 ].

CRP levels In contrast to the individually modest results for infectious agents and gliadin, the comparisons for CRP showed highly significant differences ( Table 2 ).

They were also significantly higher in the mothers of the BP patients and showed a trend in the mothers of the SZ patients, but not in the fathers. 3.

While individual tests do not withstand correction for multiple comparisons, the number of nominally significant tests and the comparisons showing the expected direction are in significant excess (permutation p=0.019 and 0.004 respectively).

Among these, the correlations between Pb and Hg, and Pb and Cd were 0.698, and 0.771, respectively, and at a P <0.01 level, and, therefore, have a highly significant correlation.

This indicates that, due to the agricultural and human activity in townships in the Aibi Lake Basin, there has been a significant trend of heavy metal accumulation in the sediment of Aibi Lake.

In the presence of IGF-I, adiposity indices (waist circumference), insulin sensitivity (Matsuda index) and ghrelin secretion (ghrelin AUC/100.000), only ghrelin AUC remained a significant predictor for fasting GH and Peak GH, and was borderline significant for GH AUC ( Table 3 ).