Excerpts

The differences are highly significant (χ 2 = 1511; p<0.0001) and consistent with the prediction that a substantial functional cost is associated with even a single nucleotide change within miRNA seed regions.

The difference between both conditions, however, proves to be highly significant ( p < 0.0001) with a higher average correlation length in the presence of fluid shear stress of 33.3 μm, compared to 24.1 μm in the case of no fluid flow.

Coefficients for the first three cycles are relatively strong and highly significant (p<.0001), while those for the last three cycles are weaker and minimally or not significant.

When adjusted for multiple comparisons with Bonferroni's correction (for n = 429 known SNPs), our finding for rs113831133 did not reach statistical significance (required P value <0.0001).

We found a highly significant association between signal in the DCR6 and escape bias overall (main effect of phenotype p<0.0001, with significant within-genotype effects after controlling for multiple comparisons in CaSR +/+ and CaSR p190/p190 groups) ( Fig 4A ).

Methylation level difference was highly significant (p<0.0001) for all CpGs in LINE-1, Alu repeats and in p16, APC SN1, ACIN1 SN1 and SN3, BCL2, CD44, TNFRSF10C.

Differences were highly significant in the chi-square test (P<0.0001).

The hazard ratio in the Cox proportional hazards model is 2.619 (95% CI 1.733–3.956) with a highly significant p -value<0.0001, indicated that the ZingiVir-H treated group had a significant recovery period.

The correlation between change in HbA1c and level of HbA1c at start of treatment with HCQ was highly significant (correlation coefficient -0.77, p<0.0001).

The association between up-regulation of CYP17A1 mRNA expression and DDTs concentration in sampled livers was highly significant (p < 0.0001).

The difference with control cells was highly significant (one-tailed Fisher’s exact test, p<0.0001).

The association between MUC1 and Rab31 expression was highly significant (Fisher’s exact test, p<0.0001) in that MUC1-positive tumors were more likely than MUC1-negative tumors to express Rab31 (n = 22, 88.0% vs. n = 8, 6.56%).

A model’s highly significant influence on the response value is indicated when the model validation value is P<0.0001.

The difference is highly significant using the Wilcoxon signed-rank test (Bonferroni corrected, p<0.0001).

Genetic differentiation between these northern and southern populations was highly significant (Exact test p<0.0001; F ST = 0.15 p<0.0001; R ST = 0.19, p<0.001) and strong population differentiation was also observed for both males (Fisher exact test p<0.0001; F ST = 0.13 P<0.002) and females (Fisher exact test p<0.0001; F ST = 0.11 p<0.003) No first generation migrants between regions were detected by Structure ( Fig 3 ) or Geneclass (100% of the individuals were correctly assigned to their putative population; Quality Index 97.45%).

Bioinformatics search for this motif using the FIMO software [ 72 ] revealed three highly significant ( P <10 −4 ) matches at the P lapA promoter region and two at P bcsD ( S3 Table ), suggesting that FleQ may bind these two regions directly.

Effects of v init on a max were statistically highly significant ( F 3, 213 = 1287, P < .0001).

The overall difference between the groups was highly significant (one-Way ANOVA, p <0.0001, F 2.31 = 57.70).

Contrary to the negative correlation, a highly significant positive correlation (p<0.0001) found in these analyses.

Moreover, 40 subjects with samples from two subsequent years showed a highly significant (p<0.0001) increase in cathelicidin concentration from visit one to visit two.

For MM, sex was found to be a highly significant (p<0.0001) main effect with males showing an overall larger MM than females.

Regression analysis of the cured percentage in untreated patients versus the odds ratio of the ten studies analyzed and presented in table S2, revealed a highly significant linear relationship (Spearman Rho = −0.842, adjusted R2 = 0.806, P<0.0001) indicating that centers with good surgical results do not benefit from pretreatment and centers with worse surgical results benefit most from pretreatment.

Our χ 2 analysis indicated that these group differences were highly significant ( Figure 7 ; χ 2 =36.7; df=1, p=0.0001), suggesting that the HIP14 knockout disrupts behavior-related correlated firing in striatum.

Population analysis Linkage disequilibrium tests performed on the whole sample were highly significant ( I A S : 0.0703; P <10 −4 ) and the pairwise variance (V D : 4.3845) was greater than the 95% critical value ( L : 2.6948).

Myostatin inhibition had no significant effect on BMD from DEXA either on the ground or in flight; however, time following launch was highly significant (p < 0.0001) and time was interactive with spaceflight (p < 0.0001) but not myostatin inhibition treatment.