Excerpts

The difference in IC50 between laboratory 12 (45) and the other PSV laboratories (1284) was highly significant (p<0.001, paired t-test) while the difference between lab 12 and the laboratories performing PBMC assays (36) was not (p = 0.29) ( Figure S3 ).

This revealed a highly significant model (adj R 2 = 0.21, p<0.001) with age (b = −32.56 (9.90), β = −0.43 (0.13), p = 0.001) and enjoyment of food (b = 13.88 (6.34), β = 0.21 (0.09), p = 0.03) as significant predictors of the change in intake.

The relationship of RGR with LWR was not significantly positive in plants of IT1, while in stressed plants it was highly significant (P≤0.001), probably explained by the lower development of DM in relation to leaf area.

Highly significant ( p <0.001) correlations among ME, AA and DP malting traits were observed.

The group * times interaction term was highly significant (p<0.001) for both BDI-II and K6.

In Kaiser-Meyer-Olkin (KMO), KMO metric for sampling sufficient degree was 0.784, and Bartlett’s test of sphericity showed extremely significant difference (P<0.001), the selected factor is suitable.

With respect to its role in differentiating between necrotic and viable tumor regions, a feature was deemed highly significant if P < 0.001, significant if 0.001 ≤ P < 0.05, and not significant if P ≥ 0.05.

Results Functional Evaluation of Low-level Visual Age-related Changes ISF perimetry (Intermediate spatial frequency channel) We measured achromatic CS at an intermediate spatial frequency for nine visual field locations (see Figure 1A for data across quadrants and Figure 2 for representative examples of age-related CS decline obtained with ISF perimetry for each age group) and found a highly significant effect of aging on mean CS [F (4,164) = 53.09, p<0.001].

However, there were highly significant differences between the annual numbers of citations received from Nature series journals when compared either with Nature , Science or Nature Immunology ( p < 0.001, Q = 6.767; p < 0.001, Q = 6.828; p < 0.001, Q = 6.791, respectively).

However, normalizing PI:C for HOMA2-IR unveiled a highly significant hyperbolic correlation (r s = -0.596; P <0.001) with AUC 5-10min C-peptide, andalso with AUC 120-150min C-peptide, only available for age 12–39 years (n = 31; r s = -0.529; P = 0.002) ( Fig 2C ).

There is a highly significant negative trend over time in the proportion of remaining founder alleles, but the variation among breeds is quite large ( b = -0.012, r 2 = 0.42, P<<0.001; Fig 3 ).

This difference was highly significant (t (119) = 16.942, p < 0.001).

A non-linear P-spline showed that the association did not follow a fully linear pattern with a highly significant non-linear component (p = 0.001) with an increased risk of all-cause mortality for HbA 1c values up to 6–7%.

A comparison pooled across all locations shows a highly significant advantage for average-image targets (Wilcoxon signed-rank test, two-tailed: W = 88, p < .001).

A two-way ANOVA showed highly significant differences ( p < 0.001) in enzyme activities for the factors, cultivar, years, and the interaction between cultivar and year.

However, the effect of SOA was highly significant (F (4.8, 86.9) = 48.17, p<.001), as well as the interaction between group and SOA (F (4.8, 86.9) = 15.33, p<.001).

The mean values of the two sessions (calculated as intercept in the robust regression in Fig 4 ) showed highly significant test-retest correlations of 0.93, 0.80, and 0.73 (p < 0.001) for heterophoria, subjective and objective fixation disparity, respectively.

The correlation is statistically highly significant for the entire curve (r = 0.82, rho = −.88, p<.001), and even more so for the Miocene interval of rapid change (15-5 Ma, r = .98, p<.001).

The 250 mg/kg and 125 mg/kg doses showed highly significant activity (p < 0.001) compared to the control group in the hot plate test.

C3a-desArg levels in the 4 mM citrate group tended to be lower as compared to the 3 mM citrate group, but the difference did not reach statistical significance (main effect of time p < 0.001, citrate group p = 0.107 and interaction effect p = 0.246).

Eight energy metabolism pathways (oxidative phosphorylation, citrate cycle, glycolysis/gluconeogenesis, pyruvate metabolism, pentose phosphate pathway, butanoate or propanoate metabolism, synthesis and degradation of ketone bodies, and fatty acid metabolism) and four amino acid metabolism pathways (arginine and proline, phenylalanine, tryptophan, and the aliphatic amino acids valine, leucine and isoleucine metabolisms) were identified, most of them at the three stages and highly significant ( p < 0.001; Table 2 ).

There were highly significant differences in culturable bacterial numbers between aquaculture and control sites over the entire study period (P<0.001, rank transformation test), with bacterial numbers significantly higher in late spring (November, 2008) and high summer through winter (January through July, 2009) than at other times (P<0.05, Student-Newman-Keuls post-test).

This difference is very highly significant for the incorporated nets (Netprotect®) (p<0.001).

The ANOVA over all the movement groups together was highly significant (F = 261.1; p < 0.001).

A permutation test showed that the differences in the metabolic profiles between high and low VO 2max -subjects were highly significant (p<0.001).