Barely Significant

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In addition, antibiotic-resistant serotype 19A emerged as replacement disease following the introduction of the first-generation pneumococcal conjugate vaccine (PCV7) in early 2000s, and became highly significant in the epidemiology of pneumococcal infections until immunization with PCV13 greatly reduced its prevalence [ 32 ].
Counts of prokaryotic cells using SEM imaging, showed a decreasing trend of cell density in the more landward-adapted species ( Fig 5 ). qPCR analysis ( Fig 6 ) corroborates (i) the SEM counting indicating that most of the prokaryotic cells imaged by SEM may belong to the bacteria Domain, and (ii) the significant decrease of bacterial numbers toward the supratidal species.
We observed small values of D (mean 0.24), indicating that the deviation of each subsample from the uniform distribution is small, and moderate values of p (mean 0.2, with 32% of the p values<0.05), suggesting that this deviation from uniformity is at best only marginally significant ( Figure 4A ).
There was an overall trend towards decreased thickness in high BMI patients, but only two measurements reached statistical significance: temporal retinal nerve fiber layer (RNFL) (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 to -0.14, p<0.01) and the choroidal region 1.0 mm nasal to fovea (SMD: -0.38, 95% CI: -0.60 to -0.16, p<0.01).