Barely Significant

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borderline significantp = 0.051.0× alphagold
Subgroup analysis As the initial outcome of OS was borderline significant (p = 0.05), we further analysed OS in two subgroups: SL (S-1 plus leucovorin) and non-SL, depending on the regimen of S-1-based combination therapy, two trials from China and Japan were allocated into the SL group.
highly significantp < 0.051.0× alphaqualifiedgold
In contrast, in the S_ st1 vs S_WT comparison, enriched highly significant terms ( p < 0.05) for down-regulated DEGs included “response to water”, “response to inorganic substance”, “response to abiotic stimulus”, “lipoprotein metabolic process”, “lipid transport”, “lipid localization”, “oxidoreduction coenzyme metabolic process”, “NADPH regeneration” and “glycerophospholipid biosynthetic process” (Fig. 5b ).
markedly significantp < 0.051.0× alphaqualified
Both cell types showed a markedly significant decrease ( p < 0.05) in the basal OCR after a 24 h combination treatment compared with the untreated control, and not surprisingly, we also observed a significant decrease ( p < 0.05) in the ECAR (extracellular acidic ratio; an indicator of glycolysis flux) following a combination treatment in both cell types ( supporting information, Figure S9 ).
In addition, multiple genes related to cytotoxic NK cell function, such as CD244 , NCR1/Nkp46 , and GZMB were reduced in smokers, but these changes did not reach statistical significance at p < 0.05 (Table 4 ).