Excerpts

Those who carried a genotype with the variant C at rs56156320 showed a trend for higher FSCN1 expression, compared with the wild-type homozygous genotypes ( p < 0.05, Fig. 1 ).

2E , t = 0.79, p > 0.05), but a marginally significant difference in staining density per cell (Fig. 2F , t = 1.38, p = 0.05), suggesting that CB1 mRNA level is higher in VTA glutamatergic neurons than in VTA GABAergic neurons. Δ 9 -THC produces conditioned place aversion in mice We then used the conditioned place preference (CPP) or aversion (CPA) procedures to compare the rewarding or aversive effects of Δ 9 -THC between VgluT2- CB1 ‒/‒ mice and their wildtype control littermates.

Though the p values did not reach statistical significance ( P < 0.05), the directions of the associations were consistent when comparing with that in whole blood samples.

Of the 246 main meta-analyses, 56 variants within 45 different genes showed nominally significant genetic associations with lung cancer ( p -value < 0.05) (Table 1 , Supplementary Table S2 ).

While no significant correlation between CAG-repeat length and absolute LQ was observed (r = −0.11; p = 0.31; polyserial correlation coeffient: −0.11), a strong trend was recognizable for a correlation between CAG-repeat length and LQ (r = −0.22; p = 0.05; polyserial correlation coeffient: r:−0.22), indicating that in homozygous women longer CAG-repeats had a tendency to be related with stronger left-handedness ( Fig. 3 ).

This difference bordered on significance, t (74) = − 1.99, p = 0.050, d = 0.53, 95% CI = [− 0.067, 0].

As for the P trend, the SPEI index showed an increase in water availability in recent years across sites, although not significant, except for LAZ, which showed a negative trend ( P < 0.05, Fig. 2 , Supplementary Fig. 4 ).

Although the difference in DNA damage was not significant, the trained groups showed a trend toward a decrease in spontaneous DNA damage as compared to untrained subjects (P > 0.05).

All peaks above the broken line are highly significant (binomial test, p < 0.05).

The increase of MMP9 did not reach statistical significance for T cells (p = 0.05, paired t-test for median fluoresecence intensity – MFI) nor did the increase of MMP2 for AdMSC (p = 0.07, paired t-test for the percentage of positive AdMSC).

2 a,b, the CO concentration also affected tensile strength and elongation at break, though the results were somewhat significant ( p < 0.05) without a consistent trend.

If p < 0.05, there was significant difference; if p < 0.01, the difference was extremely significant; if p > 0.05, there was no significant difference.

Pooled analysis Metabolites with nominally significant differences (p<0.05) and trends (0.05<p<0.10) between screening and Year 3 within the FP and AP groups Metabolites that were nominally different are reported in Table 2 with circulating concentrations reported in Table S1.

Subgroup analysis As the initial outcome of OS was borderline significant (p = 0.05), we further analysed OS in two subgroups: SL (S-1 plus leucovorin) and non-SL, depending on the regimen of S-1-based combination therapy, two trials from China and Japan were allocated into the SL group.

Results were considered significant according to GraphPad Prism: *indicates p-value 0.01 to 0.05 (significant), **Indicates p-value 0.001 to 0.01 (very significant), ***Indicates p < 0.001 (extremely significant), ns = not significant (p > 0.05).

The study found a clear dose-effect relationship, as the change in refractive error progressively increased with higher levels of PM 2.5 , CO, and O 3 , with exposure to the highest levels resulting in a considerably significant change ( p < 0.05).

Analysis of data indicated a very highly significant ( P ≤ 0.05) difference on moisture content among the samples procured from various agroclimatic conditions.

In particular, we found a highly significant percentage contribution of manure to CSE variance at GZL (4.9%, p -value < 0.05), suggesting the increasing importance of manure input in regulating SOC sequestration although it does not change the dominant impact exerted by soil on CSE (29.9%, p -value < 0.01).

Of note, although ACVR1B expression was observed to be reproducibly higher in ΔmiR-UL148D virus infected cells compared to WT infected cells in independent experiments, this did not reach statistical significance (as determined by t -test, p < 0.05).

When compared to expected frequencies of hemoglobinopathies in healthy Indians (less than 10%), this proportion (10%) is marginally significant (p = 0.05, one tailed distribution) but is preliminary in nature due to extremely small sample size.

In addition, a positive trend was observed between S100B concentrations and normalized white matter hypersensitivity (r 2 = 0.08, p < 0.05), as well as between NFL levels and normalized total gray matter (r 2 = 0.37, p < 0.01) in all players.

Cell viability At 28 days, the cell viability of the TCP-Fu-Ch scaffold was considerably significant (p < 0.05), when compared with that of the TCP-Ch scaffold; however, no significant difference was noted at the early time points (7 and 14 days) ( Fig. 3a ).

(3) In the non-running rats, the Mankin score of the PEE group showed an increasing trend compared to that of the control group ( P > 0.05).

The interaction term did not reach statistical significance (p-value < 0.05) for any of the subgroups.

greater resorption of the EMD was seen in the mock transfected group when compared to the miR-153 transfected group), the difference did not reach statistical significance ( P < 0.05).